ICOSLG

Gene Symbol	ICOSLG
Entrez Gene	23308
Alt Symbol	B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS
Species	Human
Gene Type	protein-coding
Description	inducible T-cell co-stimulator ligand
Other Description	B7 homolog 2|B7 homologue 2|B7-like protein Gl50|B7-related protein 1|ICOS ligand|transmembrane protein B7-H2 ICOS ligand
Swissprots	Q9HD18 A8MUZ1 O75144 Q9NRQ1
Accessions	ABK41909 CAC36465 CAX87084 EAX09446 EAX09447 EAX09448 O75144 AA781960 AB014553 BAA31628 AF199028 AAF34739 AF216749 AAK16241 AF289028 AAG01176 AI659611 AK090492 BAG52170 AK290192 BAF82881 AK294031 BAH11654 AK311496 AK314369 BAG36999 AK316143 BAH14514 AK316176 BAH14547 AL355690 BC064637 AAH64637 BQ005303 DC365972 HQ448129 ADQ32610 XM_011529514 XP_011527816 XM_011529515 XP_011527817 XM_011529516 XP_011527818 NM_001283050 NP_001269979 NM_001283051 NP_001269980 NM_001283052 NP_001269981 NM_015259 NP_056074
Function	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. {ECO:0000269|PubMed:10779774}.
Top Pathways	Cell adhesion molecules (CAMs), Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ICOS Ligand full length protein - ab161599 from Abcam Category Protein Source Wheat germ Species Human

Human ICOS Ligand protein fragment - ab151855 from Abcam Category Protein Source HEK 293 cells Species Human

Human ICOS Ligand protein fragment - ab182669 from Abcam Category Protein Source HEK 293 cells Species Human

Human ICOS Ligand protein fragment - ab169903 from Abcam Category Protein Source E. coli Species Human

ICOSLG / ICOSL / ICOS Ligand Antibody Blocking Peptide - LS-E3673 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICOSLG / ICOSL / ICOS Ligand Antibody Blocking Peptide - LS-E23340 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICOSLG / ICOSL / ICOS Ligand Antibody Blocking Peptide - LS-E23341 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

B7-H2/ICOSLG Recombinant Protein - H00023308-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ICOSLG-Antibody-C-term-Blocking-Peptide - BP14872b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human B7-H2 Fc Chimera, CF - 165-B7-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human B7-H2, CF - 8206-B7-100 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived, Asp19-Ser258, with a C-terminal 6-His tag

Human B7H2 protein - orb49444 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human B7-H2 protein - orb138233 from Biorbyt Category Protein Prices $570.00, $748.00 Sizes 100 μg, 200 μg Source Human Cells Species Human

Human ICOSLG His tag protein - orb83930 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Human ICOSLG Protein - abx067185 from Abbexa Category Protein Source E.coli Species Human

CD275 / ICOS Ligand - H00023308-H01 from Acris Antibodies Category Protein Prices $770.00 Sizes 25 µg Source Human HEK293T cells Species Human

CD275 / ICOS Ligand - H00023308-H02 from Acris Antibodies Category Protein Prices $770.00 Sizes 25 µg Source Human HEK293T cells Species Human

CD275 / ICOS Ligand - H00023308-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD275 / ICOS Ligand - H00023308-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Inducible Co-Stimulator Ligand, ICOSLG, Human, Recombinant - 19-C475 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source HEK293 Species Human

ICOSLG Recombinant Protein - 96-047 from ProSci Category Protein Prices $400.00 Sizes 200 µg Source HEK293 cells Species Human

ICOSLG Recombinant Protein - 96-048 from ProSci Category Protein Prices $400.00 Sizes 200 µg Source HEK293 cells Species Human

ICOSLG fusion protein - ag6392 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ICOSLG fusion protein - Ag6799 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ICOSLG Protein - BP001233-C475 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

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