| Gene Symbol | ICOSLG |
|---|---|
| Entrez Gene | 23308 |
| Alt Symbol | B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS |
| Species | Human |
| Gene Type | protein-coding |
| Description | inducible T-cell co-stimulator ligand |
| Other Description | B7 homolog 2|B7 homologue 2|B7-like protein Gl50|B7-related protein 1|ICOS ligand|transmembrane protein B7-H2 ICOS ligand |
| Swissprots | Q9HD18 A8MUZ1 O75144 Q9NRQ1 |
| Accessions | ABK41909 CAC36465 CAX87084 EAX09446 EAX09447 EAX09448 O75144 AA781960 AB014553 BAA31628 AF199028 AAF34739 AF216749 AAK16241 AF289028 AAG01176 AI659611 AK090492 BAG52170 AK290192 BAF82881 AK294031 BAH11654 AK311496 AK314369 BAG36999 AK316143 BAH14514 AK316176 BAH14547 AL355690 BC064637 AAH64637 BQ005303 DC365972 HQ448129 ADQ32610 XM_011529514 XP_011527816 XM_011529515 XP_011527817 XM_011529516 XP_011527818 NM_001283050 NP_001269979 NM_001283051 NP_001269980 NM_001283052 NP_001269981 NM_015259 NP_056074 |
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. {ECO:0000269|PubMed:10779774}. |
| Top Pathways | Cell adhesion molecules (CAMs), Intestinal immune network for IgA production |