| Gene Symbol |
PROL1
|
| Entrez Gene |
58503
|
| Alt Symbol |
BPLP, PRL1, opiorphin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proline rich, lacrimal 1
|
| Other Description |
basic proline-rich lacrimal protein|basic proline-rich protein|proline-rich 1|proline-rich protein 1
|
| Swissprots |
Q99935 A8MZ07 P85047
|
| Accessions |
CAJ32190 CAJ34589 EAX05620 Q99935 BC092438 BC141465 AAI41466 BC148720 AAI48721 CD721906 CD722615 CD723077 CD723628 CK429697 CK430664 S83198 AAB46823 NM_001302807 NP_001289736 NM_021225 NP_067048 NR_126503
|
| Function |
Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. {ECO:0000269|PubMed:17101991}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:17101991}.
|
| Tissue Specificity |
Abundantly expressed in lacrimal gland where it found in the secretory endpieces. Also expressed at modest levels in the submandibular gland.
|