PROL1

Gene Symbol PROL1
Entrez Gene 58503
Alt Symbol BPLP, PRL1, opiorphin
Species Human
Gene Type protein-coding
Description proline rich, lacrimal 1
Other Description basic proline-rich lacrimal protein|basic proline-rich protein|proline-rich 1|proline-rich protein 1
Swissprots Q99935 A8MZ07 P85047
Accessions CAJ32190 CAJ34589 EAX05620 Q99935 BC092438 BC141465 AAI41466 BC148720 AAI48721 CD721906 CD722615 CD723077 CD723628 CK429697 CK430664 S83198 AAB46823 NM_001302807 NP_001289736 NM_021225 NP_067048 NR_126503
Function Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. {ECO:0000269|PubMed:17101991}.
Subcellular Location Secreted {ECO:0000269|PubMed:17101991}.
Tissue Specificity Abundantly expressed in lacrimal gland where it found in the secretory endpieces. Also expressed at modest levels in the submandibular gland.

BPLP CRISPR/Cas9 KO Plasmid (h) - sc-412917 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BPLP HDR Plasmid (h) - sc-412917-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BPLP Double Nickase Plasmid (h) - sc-412917-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BPLP Double Nickase Plasmid (h2) - sc-412917-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BPLP CRISPR Activation Plasmid (h) - sc-412917-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BPLP CRISPR Activation Plasmid (h2) - sc-412917-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BPLP Lentiviral Activation Particles (h) - sc-412917-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BPLP Lentiviral Activation Particles (h2) - sc-412917-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BPLP siRNA (h) - sc-88882 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BPLP shRNA Plasmid (h) - sc-88882-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BPLP shRNA (h) Lentiviral Particles - sc-88882-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU000601 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17459 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17459 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PROL1 siRNA (Human) - CRJ1731 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PROL1 (NM_021225.4) - SHH383544 from Creative biogene

Category siRNA
Species Reactivities Human

PROL1 shRNA Plasmid (Human) - CHJ1731 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PROL1 miRNA 3'UTR clone - MiUTR1H-08310 from Creative biogene

Species Reactivities Human
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