PROL1

Gene Symbol	PROL1
Entrez Gene	58503
Alt Symbol	BPLP, PRL1, opiorphin
Species	Human
Gene Type	protein-coding
Description	proline rich, lacrimal 1
Other Description	basic proline-rich lacrimal protein|basic proline-rich protein|proline-rich 1|proline-rich protein 1
Swissprots	Q99935 A8MZ07 P85047
Accessions	CAJ32190 CAJ34589 EAX05620 Q99935 BC092438 BC141465 AAI41466 BC148720 AAI48721 CD721906 CD722615 CD723077 CD723628 CK429697 CK430664 S83198 AAB46823 NM_001302807 NP_001289736 NM_021225 NP_067048 NR_126503
Function	Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. {ECO:0000269|PubMed:17101991}.
Subcellular Location	Secreted {ECO:0000269|PubMed:17101991}.
Tissue Specificity	Abundantly expressed in lacrimal gland where it found in the secretory endpieces. Also expressed at modest levels in the submandibular gland.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PROL1 Gene ORF cDNA clone in cloning vector - HG13719-G from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, N-His tag - HG13719-NH from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13719-CY from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid - HG13719-UT from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, C-His tag - HG13719-CH from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13719-ACG from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13719-NY from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13719-NF from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13719-NM from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13719-CF from Sino Biological Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13719-CM from Sino Biological Species Human

Human PROL1 Gene cDNA Clone - orb144872 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human PROL1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13719-ACR from Sino Biological Species Human

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