GABARAPL2

Gene Symbol GABARAPL2
Entrez Gene 11345
Alt Symbol ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2
Species Human
Gene Type protein-coding
Description GABA(A) receptor-associated protein-like 2
Other Description MAP1 light chain 3 related protein|MAP1 light chain 3-related protein|gamma-aminobutyric acid receptor-associated protein-like 2|ganglioside expression factor 2|general protein transport factor p16|golgi-associated ATPase enhancer of 16 kDa
Swissprots Q6FG91 P60520
Accessions EAW95629 EAW95630 P60520 AB030710 BAB21548 AF077046 AAD27779 AF087848 AAK20400 AJ010569 CAA09249 AK289788 BAF82477 AK311266 AM393324 CAL38202 BC005985 AAH05985 BC014594 AAH14594 BC029601 AAH29601 BC040312 CR542217 CAG47013 DQ893101 ABM84027 DQ896373 ABM87372 NM_007285 NP_009216
Function Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000250, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}.
Subcellular Location Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22311637}.
Tissue Specificity Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:11414770}.
Top Pathways GABAergic synapse, Regulation of autophagy

GABARAPL2 (D1W9T) Rabbit mAb - 14256 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1W9T
Western blot analysis of extracts from 293T cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® GABARAPL2 siRNA I # 14239 (+) or SignalSilence® II GABARAPL2 siRNA II #14246 (+), using GABARAPL2 (D1W9T) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). The GABARAPL2 (D1W9T) Rabbit mAb confirms silencing of GABARAPL2, while the β-Actin (D6A8) Rabbit mAb is used as a loading control.

GABARAPL2 (F-14) - sc-323902 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GABARAPL2 (P-16) - sc-323901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GABARAPL2 antibody - ab62115 from Abcam

Host Sheep
Clonality Polyclonal

Anti-GABARAPL2 antibody - ab62470 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 antibody - ab72005 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 antibody - ab124193 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GABARAPL2 antibody (ab124193) at 1/100 dilution + K562 cell line lysates at 35 µg

Anti-GABARAPL2 antibody [EP4808] - ab126607 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4808
All lanes : Anti-GABARAPL2 antibody [EP4808] (ab126607) at 1/1000 dilutionLane 1 : Human fetal brain tissue lysateLane 2 : Human heart tissue lysateLane 3 : HeLa cell lysateLane 4 : Human spleen tissue lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-GABARAPL2 antibody - C-terminal - ab191616 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-GABARAPL2 antibody - C-terminal (ab191616) at 1 µgLane 2 : Anti-GABARAPL2 antibody - C-terminal (ab191616) at 2 µgLane 1 : Human brain tissue lysateLane 2 : Human brain tissue lysateLysates/proteins at 15 µg per lane.

Anti-GABARAPL2 / ATG8 Antibody (aa1-117) - LS-C63381 from LifeSpan Bioscience

Prices $665.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody (N-Terminus) - LS-C63379 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody (aa10-50) - LS-C94149 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody (Internal, clone EP4808) - LS-C152278 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4808
Western blot analysis on (A) fetal brain, (B) human heart, (C) HeLa, and (D) human spleen lysates using anti-GABARAPL2 antibody.

Anti-GABARAPL2 / ATG8 Antibody (N-Terminus) - LS-C102420 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GABARAPL2 antibody LS-C102420 Western blot of 293T cell lysate.

Anti-GABARAPL2 / ATG8 Antibody (C-Terminus) - LS-C135276 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GABARAPL2 antibody LS-C135276 Western blot of Rat Brain lysate. Antibody concentration 1 ug/ml.

Anti-GABARAPL2 / ATG8 Antibody (aa68-97, AP) - LS-C214456 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody (aa68-97, APC) - LS-C214457 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody (aa68-97, Biotin) - LS-C214458 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody - LS-C211626 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Gamma-aminobutyric acid receptor-associated protein-like 2 Antibody at 2 ug/ml + 293T whole cell lysate at 20 ug. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 13 kDa. Observed band size: 60 kDa.

Anti-GABARAPL2 / ATG8 Antibody (aa68-97, FITC) - LS-C214459 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody - LS-C211638 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Gamma-aminobutyric acid receptor-associated protein-like 2 antibody at 2 ug/ml + EC109whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 13 kDa. Observed band size: 60 kDa.

Anti-GABARAPL2 / ATG8 Antibody (HRP) - LS-C211627 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Gamma-aminobutyric acid receptor-associated protein-like 2 Antibody at 2 ug/ml + 293T whole cell lysate at 20 ug. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 13 kDa. Observed band size: 60 kDa.

Anti-GABARAPL2 / ATG8 Antibody (aa68-97, PE) - LS-C214461 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody (aa68-97, Azide-free, HRP) - LS-C214460 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GABARAPL2 / ATG8 Antibody (FITC) - LS-C211628 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Gamma-aminobutyric acid receptor-associated protein-like 2 Antibody at 2 ug/ml + 293T whole cell lysate at 20 ug. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 13 kDa. Observed band size: 60 kDa.
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