GABARAPL2

Gene Symbol GABARAPL2
Entrez Gene 11345
Alt Symbol ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2
Species Human
Gene Type protein-coding
Description GABA(A) receptor-associated protein-like 2
Other Description MAP1 light chain 3 related protein|MAP1 light chain 3-related protein|gamma-aminobutyric acid receptor-associated protein-like 2|ganglioside expression factor 2|general protein transport factor p16|golgi-associated ATPase enhancer of 16 kDa
Swissprots Q6FG91 P60520
Accessions EAW95629 EAW95630 P60520 AB030710 BAB21548 AF077046 AAD27779 AF087848 AAK20400 AJ010569 CAA09249 AK289788 BAF82477 AK311266 AM393324 CAL38202 BC005985 AAH05985 BC014594 AAH14594 BC029601 AAH29601 BC040312 CR542217 CAG47013 DQ893101 ABM84027 DQ896373 ABM87372 NM_007285 NP_009216
Function Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000250, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}.
Subcellular Location Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22311637}.
Tissue Specificity Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:11414770}.
Top Pathways GABAergic synapse, Regulation of autophagy

Human-GABARAPL2-cDNA-Clone - DC01838 from Abgent, a WuXi AppTec company

Prices $157.95
Sizes 10 µg
Species Human
Accession BC005985

GABARAPL2 - MBS1278487 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC005985

GABARAPL2 - MBS1277093 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC029601

Human GABARAPL2 ORF Clone(NM_007285.6) - CDCL164195 from Creative Biomart

Species Human
Accession NM_007285.6

Human GABARAPL2 ORF clone (NM_007285.6) - CDCR031450 from Creative biogene

Species Human

Human GABARAPL2 ORF Clone (BC029601) - CDCS413157 from Creative biogene

Species Human
Accession P60520

Human GABARAPL2 ORF Clone (BC005985) - CDCS413158 from Creative biogene

Species Human
Accession P60520
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