GABARAPL2

Gene Symbol	GABARAPL2
Entrez Gene	11345
Alt Symbol	ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2
Species	Human
Gene Type	protein-coding
Description	GABA(A) receptor-associated protein-like 2
Other Description	MAP1 light chain 3 related protein|MAP1 light chain 3-related protein|gamma-aminobutyric acid receptor-associated protein-like 2|ganglioside expression factor 2|general protein transport factor p16|golgi-associated ATPase enhancer of 16 kDa
Swissprots	Q6FG91 P60520
Accessions	EAW95629 EAW95630 P60520 AB030710 BAB21548 AF077046 AAD27779 AF087848 AAK20400 AJ010569 CAA09249 AK289788 BAF82477 AK311266 AM393324 CAL38202 BC005985 AAH05985 BC014594 AAH14594 BC029601 AAH29601 BC040312 CR542217 CAG47013 DQ893101 ABM84027 DQ896373 ABM87372 NM_007285 NP_009216
Function	Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000250, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}.
Subcellular Location	Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22311637}.
Tissue Specificity	Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:11414770}.
Top Pathways	GABAergic synapse, Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GABARAPL2 full length protein - ab157009 from Abcam Category Protein Source E. coli Species Human

Human GABARAPL2 full length protein - ab40115 from Abcam Category Protein Source E. coli Species Human

Human GABARAPL2 full length protein - ab103055 from Abcam Category Protein Source E. coli Species Human

Human GABARAPL2 full length protein - ab190023 from Abcam Category Protein Source E. coli Species Human

Human Rhodamine full length protein - ab189699 from Abcam Category Protein Source E. coli Species Human

GABARAPL2 / ATG8 Antibody Blocking Peptide - LS-E3845 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GABARAPL2 / ATG8 Antibody Blocking Peptide - LS-E18815 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GABARAPL2 / ATG8 Antibody Blocking Peptide - LS-E18816 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GATE-16/GABARAPL2 Partial Recombinant Protein - H00011345-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human GATE-16/GABARAPL2 Protein - NBP1-50966 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

GATE-16/GABARAPL2 Recombinant Protein - P3565 from Novus Biologicals Category Protein Prices $669.00 Sizes 50 µg Species Human

GATE16-Antibody-N-term-Blocking-Peptide - BP16026a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-GABARAPL2S39-Antibody-Blocking-peptide - BP3794a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-GABARAPL2S10-Antibody-Blocking-peptide - BP3793a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Recombinant Human HA-GATE-16 AMC, CF - UL-445-025 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal HA (YPYDVPDYA) tag

Recombinant Human HA-GATE-16/Apg8p2 Vinyl Sulfone, CF - UL-446-025 from R&D Systems Category Protein

Recombinant Human His6-GATE-16, CF - UL-420-500 from R&D Systems Category Protein Source E. coli-derived, Contains a 6-His tag

Recombinant Human His6-GATE-16 Rhodamine, CF - UL-426-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

Recombinant human Gamma-aminobutyric acid receptor-associated protein-like 2 (OPCA00509) - OPCA00509 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

GABARAPL2 Protein (OPPA00161) - OPPA00161 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Escherichia Coli.

Human GABARAPL2 protein - orb168377 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human GABARAPL2 protein (His Tag) - orb138896 from Biorbyt Category Protein Prices $238.00, $323.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human GABARAPL2 protein - orb245179 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Gabarapl2 Blocking Peptide - 33R-4625 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GABARAPL2 Blocking Peptide - 33R-4731 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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