GABARAPL2

Gene Symbol	GABARAPL2
Entrez Gene	11345
Alt Symbol	ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2
Species	Human
Gene Type	protein-coding
Description	GABA(A) receptor-associated protein-like 2
Other Description	MAP1 light chain 3 related protein|MAP1 light chain 3-related protein|gamma-aminobutyric acid receptor-associated protein-like 2|ganglioside expression factor 2|general protein transport factor p16|golgi-associated ATPase enhancer of 16 kDa
Swissprots	Q6FG91 P60520
Accessions	EAW95629 EAW95630 P60520 AB030710 BAB21548 AF077046 AAD27779 AF087848 AAK20400 AJ010569 CAA09249 AK289788 BAF82477 AK311266 AM393324 CAL38202 BC005985 AAH05985 BC014594 AAH14594 BC029601 AAH29601 BC040312 CR542217 CAG47013 DQ893101 ABM84027 DQ896373 ABM87372 NM_007285 NP_009216
Function	Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000250, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}.
Subcellular Location	Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22311637}.
Tissue Specificity	Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:11414770}.
Top Pathways	GABAergic synapse, Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® GABARAPL2 siRNA II - 14246 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® GABARAPL2 siRNA I - 14239 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

GABARAP CRISPR/Cas9 KO Plasmid (h) - sc-403558 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAP HDR Plasmid (h) - sc-403558-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAP Double Nickase Plasmid (h) - sc-403558-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAP Double Nickase Plasmid (h2) - sc-403558-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAP CRISPR Activation Plasmid (h) - sc-403558-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAP CRISPR Activation Plasmid (h2) - sc-403558-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAP Lentiviral Activation Particles (h) - sc-403558-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAP Lentiviral Activation Particles (h2) - sc-403558-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAPL2 siRNA (h) - sc-41958 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GABARAPL2 shRNA Plasmid (h) - sc-41958-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GABARAPL2 shRNA (h) Lentiviral Particles - sc-41958-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU009601 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9044 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9044 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05054 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05054

GABARAPL2 siRNA (Human) - CRH7772 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GATE-16/GABARAPL2 RNAi - H00011345-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

GABARAPL2 - MBS8238825 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GABARAP CRISPR/Cas9 KO Plasmid (h2) - sc-403558-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GABARAP HDR Plasmid (h2) - sc-403558-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human GABARAPL2 (NM_007285.6) - SHH298369 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human GABARAPL2(NM_007285.6) - SHG080129 from Creative biogene Category siRNA Species Reactivities Human

GABARAPL2 shRNA Plasmid (Human) - CHH7772 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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