Gene Symbol | HPGD |
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Entrez Gene | 3248 |
Alt Symbol | 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1 |
Species | Human |
Gene Type | protein-coding |
Description | hydroxyprostaglandin dehydrogenase 15-(NAD) |
Other Description | 15-hydroxyprostaglandin dehydrogenase [NAD(+)]|NAD+-dependent 15-hydroxyprostaglandin dehydrogenase|prostaglandin dehydrogenase 1|short chain dehydrogenase/reductase family 36C member 1|short chain dehydrogenase/reductase family 36C, member 1 |
Swissprots | Q12998 B4DV57 E7EV11 D3DP43 B4DTA4 B4DU74 Q06F08 O00749 P15428 |
Accessions | AAF29493 ABI75347 CAY55949 EAX04734 EAX04735 EAX04736 EAX04737 P15428 AI435471 AK058013 AK296642 BAH12408 AK300125 BAG61916 AK300524 BAG62236 AK300940 BAG62569 AK314624 BAG37190 BC007691 BC018986 AAH18986 DC420578 J05594 AAA89174 L76465 AAA89175 U63296 AAB53034 X82460 CAA57843 XM_011531907 XP_011530209 XR_938728 NM_000860 NP_000851 NM_001145816 NP_001139288 NM_001256301 NP_001243230 NM_001256305 NP_001243234 NM_001256306 NP_001243235 NM_001256307 NP_001243236 |
Function | Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. {ECO:0000269|PubMed:10837478, ECO:0000269|PubMed:15574495, ECO:0000269|PubMed:16828555}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Detected in colon epithelium (at protein level). {ECO:0000269|PubMed:15574495}. |
Top Pathways | Transcriptional misregulation in cancer |
PGDH (H-3) - sc-271418 from Santa Cruz Biotechnology
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PGDH (N-13) - sc-48910 from Santa Cruz Biotechnology
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PGDH (FL-266) - sc-98907 from Santa Cruz Biotechnology
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PGDH (C-13) - sc-48908 from Santa Cruz Biotechnology
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Anti-Prostaglandin dehydrogenase 1 antibody - ab118185 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody - ab96732 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody - ab115577 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody - ab26076 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody - ab89826 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody - ab37148 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody [1C12] - ab118005 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody [EPR12348(B)] - ab178682 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody [EPR12349(B)] - ab170924 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody [EPR14332] - ab187160 from Abcam
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Anti-Prostaglandin dehydrogenase 1 antibody [EPR14332-19] - ab187161 from Abcam
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Anti-15-PGDH / HPGD Antibody (clone 1C12) - LS-C172693 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody (clone 1C10) - LS-C172692 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody IHC-plus⢠- LS-B115 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody (clone 1D8) - LS-C133894 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody (aa205-266) IHC-plus⢠- LS-B11719 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody (clone 1E9) - LS-C337266 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody (clone 2F5) - LS-C172714 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody (clone 2C10) - LS-C172619 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody (aa255-266) IHC-plus⢠- LS-B3599 from LifeSpan Bioscience
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Anti-15-PGDH / HPGD Antibody (Biotin) - LS-C83824 from LifeSpan Bioscience
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