EDEM2

Gene Symbol EDEM2
Entrez Gene 55741
Alt Symbol C20orf31, C20orf49, bA4204.1
Species Human
Gene Type protein-coding
Description ER degradation enhancer, mannosidase alpha-like 2
Other Description ER degradation-enhancing alpha-mannosidase-like 2|ER degradation-enhancing alpha-mannosidase-like protein 2|ER degradation-enhancing-mannosidase-like protein 2
Swissprots Q9NVE6 Q6IA89 Q6GU33 B4DTG9 Q6UWZ4 Q9BV94 Q9H4U0 Q9H886 Q9NTL9
Accessions EAW76225 EAW76226 EAW76227 EAW76228 Q9BV94 AF086313 AI919497 AK001645 BAA91806 AK023931 BAB14731 AK096016 AK293583 BAG57052 AK298794 BAG60931 AK300212 BAG61981 AK303816 BAG64766 AY007088 AY358580 AAQ88943 BC001371 AAH01371 BC016184 AAH16184 BP297100 BU188881 CR457266 CAG33547 NM_001145025 NP_001138497 NM_018217 NP_060687 NR_026728
Function Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. {ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:15579471, ECO:0000269|PubMed:25092655}.
Subcellular Location Secreted. Endoplasmic reticulum lumen.
Tissue Specificity Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. {ECO:0000269|PubMed:15537790}.
Top Pathways Protein processing in endoplasmic reticulum

EDEM2 (N-14) - sc-87706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
EDEM2 (N-14): sc-87706. Western blot analysis of EDEM2 expression in K-562 whole cell lysate.

EDEM2 (P-17) - sc-87707 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

EDEM2 (JD-32) - sc-130460 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
EDEM2 (JD-32): sc-130460. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human stomach tissue showing extracellular localization.

Anti-C20orf31 antibody - ab57633 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57633 C20orf31 antibody at 1ug/ml.

Anti-C20orf31 antibody - ab168111 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-C20orf31 antibody (ab168111) at 1 µg/mlLane 1 : C20orf31 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L)-HRP at 1/2500 dilution

Anti-C20orf31 antibody [2E4] - ab112009 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2E4
ab112009, at 2.5µg/ml, staining C20orf31 in formalin-fixed, paraffin-embedded Human heart tissue by Immunohistochemistry.

Anti-C20orf31 antibody [EPR14043] - ab181218 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14043
Anti-C20orf31 antibody [EPR14043] (ab181218) at 1/1000 dilution + HepG2 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG HRP (ab136636) at 1/500 dilution

Anti-C20orf31 antibody [EPR14043-24] - ab180522 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14043-24
Anti-C20orf31 antibody [EPR14043-24] (ab180522) at 1/2000 dilution + IM9 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-EDEM2 Antibody - LS-C311099 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EDEM2 Antibody (C-Terminus) - LS-C305983 from LifeSpan Bioscience

Prices $460.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of EDEM2 antibody LS-X234997.

Anti-EDEM2 Antibody (clone 2E4) IHC-plus™ - LS-B4529 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2E4
Anti-EDEM2 / C20orf31 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4529 concentration 2.5 ug/ml.

EDEM2 Antibody (2E4) - H00055741-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E4

EDEM2 Antibody - NBP2-37921 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EDEM2 Antibody [NBP2-37921] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG. Lane 4: Human Plasma

EDEM2 Antibody - H00055741-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: EDEM2 Antibody [H00055741-B01] - analysis of C20orf31 expression in transfected 293T cell line by C20orf31 MaxPab polyclonal antibody (B01). Lane1: C20orf31 transfected lysate (64.80 KDa). Lane2: Non-transfected lysate.

EDEM2 Antibody - H00055741-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: EDEM2 Antibody [H00055741-D01P] - Analysis of EDEM2 expression in transfected 293T cell line by EDEM2 polyclonal antibody.Lane 1: EDEM2 transfected lysate(64.80 KDa).Lane 2: Non-transfected lysate.

Rabbit Anti-C20orf31 Polyclonal Antibody - bs-15110R from Bioss

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-C20orf31 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-15110R-A350 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-C20orf31 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-15110R-A488 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-C20orf31 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-15110R-A555 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-C20orf31 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-15110R-A647 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-C20orf31 Polyclonal Antibody, Cy5 Conjugated - bs-15110R-Cy5 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-C20orf31 Polyclonal Antibody, Cy5.5 Conjugated - bs-15110R-Cy5.5 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-C20orf31 Polyclonal Antibody, Cy7 Conjugated - bs-15110R-Cy7 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-C20orf31 Polyclonal Antibody, FITC Conjugated - bs-15110R-FITC from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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