| Gene Symbol |
EDEM2
|
| Entrez Gene |
55741
|
| Alt Symbol |
C20orf31, C20orf49, bA4204.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ER degradation enhancer, mannosidase alpha-like 2
|
| Other Description |
ER degradation-enhancing alpha-mannosidase-like 2|ER degradation-enhancing alpha-mannosidase-like protein 2|ER degradation-enhancing-mannosidase-like protein 2
|
| Swissprots |
Q9NVE6 Q6IA89 Q6GU33 B4DTG9 Q6UWZ4 Q9BV94 Q9H4U0 Q9H886 Q9NTL9
|
| Accessions |
EAW76225 EAW76226 EAW76227 EAW76228 Q9BV94 AF086313 AI919497 AK001645 BAA91806 AK023931 BAB14731 AK096016 AK293583 BAG57052 AK298794 BAG60931 AK300212 BAG61981 AK303816 BAG64766 AY007088 AY358580 AAQ88943 BC001371 AAH01371 BC016184 AAH16184 BP297100 BU188881 CR457266 CAG33547 NM_001145025 NP_001138497 NM_018217 NP_060687 NR_026728
|
| Function |
Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. {ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:15579471, ECO:0000269|PubMed:25092655}.
|
| Subcellular Location |
Secreted. Endoplasmic reticulum lumen.
|
| Tissue Specificity |
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. {ECO:0000269|PubMed:15537790}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|