EDEM2

Gene Symbol	EDEM2
Entrez Gene	55741
Alt Symbol	C20orf31, C20orf49, bA4204.1
Species	Human
Gene Type	protein-coding
Description	ER degradation enhancer, mannosidase alpha-like 2
Other Description	ER degradation-enhancing alpha-mannosidase-like 2|ER degradation-enhancing alpha-mannosidase-like protein 2|ER degradation-enhancing-mannosidase-like protein 2
Swissprots	Q9NVE6 Q6IA89 Q6GU33 B4DTG9 Q6UWZ4 Q9BV94 Q9H4U0 Q9H886 Q9NTL9
Accessions	EAW76225 EAW76226 EAW76227 EAW76228 Q9BV94 AF086313 AI919497 AK001645 BAA91806 AK023931 BAB14731 AK096016 AK293583 BAG57052 AK298794 BAG60931 AK300212 BAG61981 AK303816 BAG64766 AY007088 AY358580 AAQ88943 BC001371 AAH01371 BC016184 AAH16184 BP297100 BU188881 CR457266 CAG33547 NM_001145025 NP_001138497 NM_018217 NP_060687 NR_026728
Function	Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. {ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:15579471, ECO:0000269|PubMed:25092655}.
Subcellular Location	Secreted. Endoplasmic reticulum lumen.
Tissue Specificity	Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. {ECO:0000269|PubMed:15537790}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

C20orf31 protein (His-DHFR tag) - ab127816 from Abcam Category Protein Prices $402.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human EDEM2 Protein - H00055741-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EDEM2 Partial Recombinant Protein - H00055741-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human EDEM2 protein (His Tag) - orb138732 from Biorbyt Category Protein Prices $417.00, $859.00 Sizes 20 μg, 100 μg Source Human Cells Species Human

EDEM2 - H00055741-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EDEM2 - H00055741-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EDEM2 - H00055741-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EDEM2 - H00055741-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EDEM2 fusion protein - ag1755 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human EDEM2, His tagged - EDEM2-196H from Creative Biomart Category Protein Source Human Cells Species Human

Human EDEM2 / C20orf31 Protein (His Tag) - 15687-H08H-100 from Sino Biological Category Protein Source Human Cells Species Human

Recombinant Human ER degradation-enhancing alpha-mannosidase-like 2(EDEM2) - CSB-YP861146HU CSB-EP861146HU CSB-BP861146HU CSB-MP861146HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EDEM2 Blocking Peptide - 6633BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 μg

EDEM2, Peptide - MBS843641 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

Recombinant Human EDEM2 / C20orf31 Protein (His tag) - PKSH030522 from Elabscience Category Protein Source Human Cell Species Human

EDEM2 Protein - NBP2-37921PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

EDEM2 Peptide, Human - M34GP04713H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human EDEM2 / C20orf31 Protein (His Tag) - 15687-H08H from ABclonal Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

EDEM2 / C20orf31, Recombinant Protein - MBS2545215 from MyBioSource Category Protein Prices $375.00, $905.00 Sizes 20 µg, 100 µg Source Human Cells

ER degradation-enhancing alpha-mannosidase-like 2 (EDEM2), Recombinant Protein - MBS1417820 from MyBioSource Category Protein Prices $1,355.00, $1,355.00, $1,570.00, $1,570.00, $2,245.00, $2,245.00, $2,710.00, $2,710.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human EDEM2 Protein, GST-tagged - EDEM2-3051H from Creative Biomart Category Protein Source Wheat Germ Species Human

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