EDEM2

Gene Symbol	EDEM2
Entrez Gene	55741
Alt Symbol	C20orf31, C20orf49, bA4204.1
Species	Human
Gene Type	protein-coding
Description	ER degradation enhancer, mannosidase alpha-like 2
Other Description	ER degradation-enhancing alpha-mannosidase-like 2|ER degradation-enhancing alpha-mannosidase-like protein 2|ER degradation-enhancing-mannosidase-like protein 2
Swissprots	Q9NVE6 Q6IA89 Q6GU33 B4DTG9 Q6UWZ4 Q9BV94 Q9H4U0 Q9H886 Q9NTL9
Accessions	EAW76225 EAW76226 EAW76227 EAW76228 Q9BV94 AF086313 AI919497 AK001645 BAA91806 AK023931 BAB14731 AK096016 AK293583 BAG57052 AK298794 BAG60931 AK300212 BAG61981 AK303816 BAG64766 AY007088 AY358580 AAQ88943 BC001371 AAH01371 BC016184 AAH16184 BP297100 BU188881 CR457266 CAG33547 NM_001145025 NP_001138497 NM_018217 NP_060687 NR_026728
Function	Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. {ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:15579471, ECO:0000269|PubMed:25092655}.
Subcellular Location	Secreted. Endoplasmic reticulum lumen.
Tissue Specificity	Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. {ECO:0000269|PubMed:15537790}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EDEM2-Over-expression-Lysate - LY13708a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

EDEM2 293T Cell Transient Overexpression Lysate(Denatured) - H00055741-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

EDEM2 overexpression lysate - LY402658 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

EDEM2 overexpression lysate - LY428649 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

EDEM2 293 Cell Lysate - 402317 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

EDEM2 Overexpression Lysate (Denatured) - H00055741-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

EDEM2 Overexpression Lysate (Native) - NBL1-10109 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

EDEM2 Over-expression Lysate Product - GWB-CACD60 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human EDEM2 / C20orf31 HEK293 Cell Lysate (WB positive control) - 15687-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

EDEM2 Overexpression Lysate (Denatured) - H00055741-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human EDEM2 Human Cells Transfected Lysate (positive control) (denatured) - orb174787 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human EDEM2 Knockdown Stable Cell Line - CSC-DC004713 from Creative biogene Category Cell Line Species Human

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