EDEM2

Gene Symbol EDEM2
Entrez Gene 55741
Alt Symbol C20orf31, C20orf49, bA4204.1
Species Human
Gene Type protein-coding
Description ER degradation enhancer, mannosidase alpha-like 2
Other Description ER degradation-enhancing alpha-mannosidase-like 2|ER degradation-enhancing alpha-mannosidase-like protein 2|ER degradation-enhancing-mannosidase-like protein 2
Swissprots Q9NVE6 Q6IA89 Q6GU33 B4DTG9 Q6UWZ4 Q9BV94 Q9H4U0 Q9H886 Q9NTL9
Accessions EAW76225 EAW76226 EAW76227 EAW76228 Q9BV94 AF086313 AI919497 AK001645 BAA91806 AK023931 BAB14731 AK096016 AK293583 BAG57052 AK298794 BAG60931 AK300212 BAG61981 AK303816 BAG64766 AY007088 AY358580 AAQ88943 BC001371 AAH01371 BC016184 AAH16184 BP297100 BU188881 CR457266 CAG33547 NM_001145025 NP_001138497 NM_018217 NP_060687 NR_026728
Function Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. {ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:15579471, ECO:0000269|PubMed:25092655}.
Subcellular Location Secreted. Endoplasmic reticulum lumen.
Tissue Specificity Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. {ECO:0000269|PubMed:15537790}.
Top Pathways Protein processing in endoplasmic reticulum

EDEM2 CRISPR/Cas9 KO Plasmid (h) - sc-408453 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDEM2 HDR Plasmid (h) - sc-408453-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDEM2 Double Nickase Plasmid (h) - sc-408453-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDEM2 Double Nickase Plasmid (h2) - sc-408453-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDEM2 CRISPR Activation Plasmid (h) - sc-408453-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDEM2 CRISPR Activation Plasmid (h2) - sc-408453-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDEM2 Lentiviral Activation Particles (h) - sc-408453-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDEM2 Lentiviral Activation Particles (h2) - sc-408453-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDEM2 siRNA (h) - sc-77226 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EDEM2 shRNA Plasmid (h) - sc-77226-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EDEM2 shRNA (h) Lentiviral Particles - sc-77226-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EDEM2 RNAi - H00055741-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU029701 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7652 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7652 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EDEM2 siRNA (Human) - CRJ0879 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EDEM2 - MBS8224905 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EDEM2 (NM_018217.2) - SHH283129 from Creative biogene

Category siRNA
Species Reactivities Human

EDEM2 shRNA Plasmid (Human) - CHJ0879 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EDEM2 miRNA 3'UTR clone - MiUTR3H-11142 from Creative biogene

Species Reactivities Human

EDEM2 miRNA 3'UTR clone - MiUTR3H-11143 from Creative biogene

Species Reactivities Human
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