| Gene Symbol |
NTAN1
|
| Entrez Gene |
123803
|
| Alt Symbol |
PNAA, PNAD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-terminal asparagine amidase
|
| Other Description |
protein N-terminal Asn amidase|protein N-terminal asparagine amidase|protein N-terminal asparagine amidohydrolase|protein NH2-terminal asparagine deamidase|protein NTN-amidase
|
| Swissprots |
Q7Z4Z0 Q96AB6
|
| Accessions |
EAW54749 Q96AB6 AF092440 AAP97215 AK092915 BC017336 AAH17336 BF939373 DC383993 HQ447215 ADQ31702 HY036316 XM_011522355 XP_011520657 XM_011546694 XP_011544996 NM_001270766 NP_001257695 NM_001270767 NP_001257696 NM_173474 NP_775745
|
| Function |
Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N- terminal peptidyl Asn. {ECO:0000269|PubMed:21375249}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|