NTAN1

Gene Symbol NTAN1
Entrez Gene 123803
Alt Symbol PNAA, PNAD
Species Human
Gene Type protein-coding
Description N-terminal asparagine amidase
Other Description protein N-terminal Asn amidase|protein N-terminal asparagine amidase|protein N-terminal asparagine amidohydrolase|protein NH2-terminal asparagine deamidase|protein NTN-amidase
Swissprots Q7Z4Z0 Q96AB6
Accessions EAW54749 Q96AB6 AF092440 AAP97215 AK092915 BC017336 AAH17336 BF939373 DC383993 HQ447215 ADQ31702 HY036316 XM_011522355 XP_011520657 XM_011546694 XP_011544996 NM_001270766 NP_001257695 NM_001270767 NP_001257696 NM_173474 NP_775745
Function Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N- terminal peptidyl Asn. {ECO:0000269|PubMed:21375249}.
Subcellular Location Cytoplasm {ECO:0000250}.

PNAd CRISPR/Cas9 KO Plasmid (h) - sc-410272 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNAd HDR Plasmid (h) - sc-410272-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNAd Double Nickase Plasmid (h) - sc-410272-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNAd Double Nickase Plasmid (h2) - sc-410272-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNAd CRISPR Activation Plasmid (h) - sc-410272-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNAd CRISPR Activation Plasmid (h2) - sc-410272-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNAd Lentiviral Activation Particles (h) - sc-410272-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNAd Lentiviral Activation Particles (h2) - sc-410272-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNAd siRNA (h) - sc-62832 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PNAd shRNA Plasmid (h) - sc-62832-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PNAd shRNA (h) Lentiviral Particles - sc-62832-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU010681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15557 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15557 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NTAN1 siRNA (Human) - CRJ4741 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NTAN1 (NM_173474.3) - SHH355640 from Creative biogene

Category siRNA
Species Reactivities Human

Human NTAN1 siRNA - orb275242 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NTAN1 shRNA Plasmid (Human) - CHJ4741 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NTAN1 miRNA 3'UTR clone - MiUTR3H-15617 from Creative biogene

Species Reactivities Human
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