| Gene Symbol | NTAN1 |
|---|---|
| Entrez Gene | 123803 |
| Alt Symbol | PNAA, PNAD |
| Species | Human |
| Gene Type | protein-coding |
| Description | N-terminal asparagine amidase |
| Other Description | protein N-terminal Asn amidase|protein N-terminal asparagine amidase|protein N-terminal asparagine amidohydrolase|protein NH2-terminal asparagine deamidase|protein NTN-amidase |
| Swissprots | Q7Z4Z0 Q96AB6 |
| Accessions | EAW54749 Q96AB6 AF092440 AAP97215 AK092915 BC017336 AAH17336 BF939373 DC383993 HQ447215 ADQ31702 HY036316 XM_011522355 XP_011520657 XM_011546694 XP_011544996 NM_001270766 NP_001257695 NM_001270767 NP_001257696 NM_173474 NP_775745 |
| Function | Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N- terminal peptidyl Asn. {ECO:0000269|PubMed:21375249}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |