| Gene Symbol |
FGF23
|
| Entrez Gene |
8074
|
| Alt Symbol |
ADHR, FGFN, HPDR2, HYPF, PHPTC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fibroblast growth factor 23
|
| Other Description |
phosphatonin|tumor-derived hypophosphatemia inducing factor
|
| Swissprots |
Q9GZV9 Q4V758
|
| Accessions |
AAP97433 AAS59157 CAI93447 CAT81644 CAT82838 CBX33262 EAW88848 Q9GZV9 AB037973 BAB13477 AB047858 BAB55889 AF263537 AAG09917 AY358323 AAQ88689 BC069333 AAH69333 BC096713 AAH96713 BC098147 AAH98147 BC098252 AAH98252 NM_020638 NP_065689
|
| Function |
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. {ECO:0000250, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:16638743}. Note=Secretion is dependent on O-glycosylation.
|
| Tissue Specificity |
Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). {ECO:0000269|PubMed:12952917}.
|
| Top Pathways |
Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton
|
