FGF23

Gene Symbol	FGF23
Entrez Gene	8074
Alt Symbol	ADHR, FGFN, HPDR2, HYPF, PHPTC
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor 23
Other Description	phosphatonin|tumor-derived hypophosphatemia inducing factor
Swissprots	Q9GZV9 Q4V758
Accessions	AAP97433 AAS59157 CAI93447 CAT81644 CAT82838 CBX33262 EAW88848 Q9GZV9 AB037973 BAB13477 AB047858 BAB55889 AF263537 AAG09917 AY358323 AAQ88689 BC069333 AAH69333 BC096713 AAH96713 BC098147 AAH98147 BC098252 AAH98252 NM_020638 NP_065689
Function	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. {ECO:0000250, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.
Subcellular Location	Secreted {ECO:0000269|PubMed:16638743}. Note=Secretion is dependent on O-glycosylation.
Tissue Specificity	Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). {ECO:0000269|PubMed:12952917}.
Top Pathways	Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human FGF 23 full length protein - ab108553 from Abcam Category Protein Prices $315.00 Sizes 10 µg Source HEK 293 cells Species Human

Active mouse FGF 23 full length protein - ab108942 from Abcam Category Protein Prices $315.00 Sizes 10 µg Source HEK 293 cells Species Mouse

Active mouse FGF 23 full length protein - ab186082 from Abcam Category Protein Prices $110.00, $308.00 Sizes 5 µg, 20 µg Source E. coli Species Mouse

FGF 23 peptide - ab109073 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human FGF 23 full length protein - ab104163 from Abcam Category Protein Source E. coli Species Human

FGF23 Antibody Blocking Peptide - LS-E27737 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FGF23 Antibody Blocking Peptide - LS-E26241 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FGF-23 Protein - NBP2-35026 from Novus Biologicals Category Protein Prices $69.00, $169.00, $3,469.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

FGF23 Recombinant Protein - GTX48113-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

FGF23 blocking peptide - GTX89195-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human FGF-23 - 2604-FG-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Tyr25-Ile251, with a C-terminal 6-His tag

Recombinant Human FGF-23, CF - 2604-FG-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Tyr25-Ile251, with a C-terminal 6-His tag

FGF 23 Protein (OPPA00636) - OPPA00636 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

FGF23 Protein (OPPA02583) - OPPA02583 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human FGF 23 protein (His Tag) - orb80323 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

Human FGF23 protein - orb168346 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

Human FGF 23 protein - orb168354 from Biorbyt Category Protein Prices $187.00, $323.00, $4,046.00 Sizes 5 μg, 20 μg, 1 mg Source E. coli

Human FGF-23 protein - orb107724 from Biorbyt Category Protein Prices $221.00, $357.00, $689.00, $1,165.00 Sizes 5 μg, 20 μg, 100 μg, 250 μg Source E.coli

Human FGF-23 protein - orb180271 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source Human Cells Species Human

Goat anti Fgf23 antibody Immunizing peptide - orb66252 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

FGF23 protein - 30R-AF040 from Fitzgerald Category Protein Prices $225.00 Sizes 20 µg Source E.coli

Human FGF23 Protein - abx066603 from Abbexa Category Protein Source E.coli Species Human

Human FGF23 Protein - abx066605 from Abbexa Category Protein Source E.coli Species Human

Human FGF23 Protein - abx066604 from Abbexa Category Protein Source E.coli Species Human

FGF 23 Peptide - AC21-1073-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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