FGF23

Gene Symbol FGF23
Entrez Gene 8074
Alt Symbol ADHR, FGFN, HPDR2, HYPF, PHPTC
Species Human
Gene Type protein-coding
Description fibroblast growth factor 23
Other Description phosphatonin|tumor-derived hypophosphatemia inducing factor
Swissprots Q9GZV9 Q4V758
Accessions AAP97433 AAS59157 CAI93447 CAT81644 CAT82838 CBX33262 EAW88848 Q9GZV9 AB037973 BAB13477 AB047858 BAB55889 AF263537 AAG09917 AY358323 AAQ88689 BC069333 AAH69333 BC096713 AAH96713 BC098147 AAH98147 BC098252 AAH98252 NM_020638 NP_065689
Function Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. {ECO:0000250, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.
Subcellular Location Secreted {ECO:0000269|PubMed:16638743}. Note=Secretion is dependent on O-glycosylation.
Tissue Specificity Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). {ECO:0000269|PubMed:12952917}.
Top Pathways Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton

FGF-23 (FL-251) - sc-50292 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FGF-23 (FL-251): sc-50292. Western blot analysis of FGF-23 expression in human PBL whole cell lysate.

FGF-23 (N-20) - sc-16849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FGF-23 (N-20): sc-16849. Western blot analysis of FGF-23 expression in mouse heart tissue extract.

FGF-23 (P-15) - sc-27249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FGF-23 (P-15): sc-27249. Western blot analysis of FGF-23 expression in human PBL whole cell lysate.

Anti-FGF 23 antibody - ab56326 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-FGF 23 antibody (ab56326) at 0.5 µg/ml + Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer)

Anti-FGF 23 antibody - ab47117 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab47117 stained SKNSH cells. The cells were 4% PFA fixed (10mins) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab47117, 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899 Dylight 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-FGF 23 antibody - ab98000 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGF 23 antibody (ab98000) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : MOLT4 (Human acute lymphoblastic leukemia cell line) Whole Cell LysateLane 3 : Bone Marrow (Human) Tissue Lysate - adult normal tissueLane 4 : Bone (Human) Tissue Lysate - tumor tissue (ab29359)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-FGF 23 antibody - ab192497 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF 23 antibody [10H8] - ab134781 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10H8
Anti-FGF 23 antibody [10H8] (ab134781) at 1/1000 dilution + Recombinant Human FGF 23 protein at 0.1 µg

Anti-FGF 23 antibody [10H8] - ab136548 from Abcam

Host Mouse
Clonality Monoclonal
Clone 10H8

Anti-FGF 23 antibody [FGF23638] - ab190702 from Abcam

Prices $368.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone FGF23638

Anti-FGF 23 antibody - C-terminal - ab190673 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FGF 23 antibody - C-terminal (ab190673) at 1/500 dilution + THP-1 cell extracts

Anti-FGF23 Antibody (aa79-160, Biotin) - LS-C299251 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody (aa157-238, Biotin) - LS-C300475 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody (aa151-200) - LS-C119518 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HUVEC cells, using FGF23 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FGF23 Antibody (aa25-251, Biotin) - LS-C300606 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody (aa24-126, Biotin) - LS-C300607 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody (aa157-238, FITC) - LS-C301954 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody (aa79-160, FITC) - LS-C303440 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody (aa24-126, FITC) - LS-C305675 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody (aa25-251, FITC) - LS-C305679 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 / FGF-23 Antibody (aa42-251) - LS-C311822 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody - LS-C307534 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-FGF23 Antibody - LS-C340726 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody - LS-C340819 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF23 Antibody - LS-C341927 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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