FGF23

Gene Symbol FGF23
Entrez Gene 8074
Alt Symbol ADHR, FGFN, HPDR2, HYPF, PHPTC
Species Human
Gene Type protein-coding
Description fibroblast growth factor 23
Other Description phosphatonin|tumor-derived hypophosphatemia inducing factor
Swissprots Q9GZV9 Q4V758
Accessions AAP97433 AAS59157 CAI93447 CAT81644 CAT82838 CBX33262 EAW88848 Q9GZV9 AB037973 BAB13477 AB047858 BAB55889 AF263537 AAG09917 AY358323 AAQ88689 BC069333 AAH69333 BC096713 AAH96713 BC098147 AAH98147 BC098252 AAH98252 NM_020638 NP_065689
Function Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. {ECO:0000250, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.
Subcellular Location Secreted {ECO:0000269|PubMed:16638743}. Note=Secretion is dependent on O-glycosylation.
Tissue Specificity Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). {ECO:0000269|PubMed:12952917}.
Top Pathways Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton

FGF-23 CRISPR/Cas9 KO Plasmid (h) - sc-401831 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGF-23 HDR Plasmid (h) - sc-401831-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGF-23 Double Nickase Plasmid (h) - sc-401831-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGF-23 Double Nickase Plasmid (h2) - sc-401831-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGF-23 CRISPR Activation Plasmid (h) - sc-401831-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGF-23 CRISPR Activation Plasmid (h2) - sc-401831-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGF-23 Lentiviral Activation Particles (h) - sc-401831-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGF-23 Lentiviral Activation Particles (h2) - sc-401831-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FGF-23 siRNA (h) - sc-39486 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FGF-23 shRNA Plasmid (h) - sc-39486-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FGF-23 shRNA (h) Lentiviral Particles - sc-39486-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8659 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8659 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FGF23 siRNA (Human) - CRH5357 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FGF23 - MBS8231988 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FGF23 (NM_020638.2) - SHH294529 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FGF23(NM_020638.2) - SHH057665 from Creative biogene

Category siRNA
Species Reactivities Human

Human FGF23 siRNA - orb265859 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FGF23 shRNA Plasmid (Human) - CHH5357 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FGF23 miRNA 3'UTR clone - MiUTR1H-03631 from Creative biogene

Species Reactivities Human
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