| Gene Symbol | PRKAA2 |
|---|---|
| Entrez Gene | 5563 |
| Alt Symbol | AMPK, AMPK2, AMPKa2, PRKAA |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, AMP-activated, alpha 2 catalytic subunit |
| Other Description | 5'-AMP-activated protein kinase catalytic subunit alpha-2|5'-AMP-activated protein kinase, catalytic alpha-2 chain|ACACA kinase|AMP-activated protein kinase alpha-2 subunit variant 2|AMP-activated protein kinase alpha-2 subunit variant 3|AMPK alpha 2|AMPK subunit alpha-2|AMPK-alpha-2 chain|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase |
| Swissprots | Q9H1E8 Q9UD43 P54646 |
| Accessions | AAB32732 EAX06650 P54646 AI732856 AK314011 BAG36722 AL596521 AL710110 BC043195 BC069680 AAH69680 BC069740 AAH69740 BC069823 AAH69823 BM979925 CB985850 CF552084 DA710012 EF056019 ABK30810 FJ200485 ACO54882 FJ200486 ACO54883 HQ628625 AER93375 U06454 AAA64745 NM_006252 NP_006243 |
| Function | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters. |
| Top Pathways | Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway |
Human PRKAA2 / AMPK Alpha 2 ELISA Kit (Sandwich ELISA) - LS-F10706 from LifeSpan Bioscience
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5'-AMP-activated protein kinase catalytic subunit alpha-2, PRKAA2, Human, ELISA Kit - E10189h from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Human, ELISA Kit - E-EL-H0318 from ARP American Research Products
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Protein Kinase, AMP Activated Alpha 1 (PRKAa1), Human, ELISA Kit - SEA679Hu from ARP American Research Products
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Protein Kinase, AMP Activated Beta 1 (PRKAb1), Human, ELISA Kit - SEB671Hu from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Mouse, ELISA Kit - E-EL-M1361 from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Rat, ELISA Kit - E-EL-R0738 from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Rabbit, ELISA Kit - E-EL-RB0954 from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Chicken, ELISA Kit - E-EL-Ch1692 from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Porcine, ELISA Kit - E-EL-P2153 from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Sheep, ELISA Kit - E-EL-S0008 from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Guinea Pig, ELISA Kit - E-EL-GP0107 from ARP American Research Products
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Phosphorylated Adenosine Monophosphate Activated Protein Kinase, AMPK, Monkey, ELISA Kit - E-EL-MK1526 from ARP American Research Products
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Human AMPK ELISA Kit - HA0050 from NeoScientific
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Anserine AMPK ELISA Kit - AA0050 from NeoScientific
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Human AMPK(Phosphorylated Adenosine Monophosphate Activated Protein Kinase) ELISA Kit - E-EL-H0318 from Elabscience
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Human AMPK (Phosphorylated Adenosine Monophosphate Activated Protein Kinase) CLIA Kit - E-CL-H0257 from Elabscience
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Adenosine Monophosphate Activated Protein, ELISA Kit - MBS014339 from MyBioSource
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Adenosine Monophosphate Activated Protein, ELISA Kit - MBS071432 from MyBioSource
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Adenosine Monophosphate Activated Protein, ELISA Kit - MBS083506 from MyBioSource
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Adenosine Monophosphate Activated Protein, ELISA Kit - MBS027455 from MyBioSource
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Adenosine Monophosphate Activated Protein, ELISA Kit - MBS029776 from MyBioSource
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Adenosine Monophosphate Activated Protein, ELISA Kit - MBS024414 from MyBioSource
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Adenosine Monophosphate Activated Protein, ELISA Kit - MBS013408 from MyBioSource
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Adenosine Monophosphate Activated Protein, ELISA Kit - MBS046958 from MyBioSource
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