PRKAA2

Gene Symbol	PRKAA2
Entrez Gene	5563
Alt Symbol	AMPK, AMPK2, AMPKa2, PRKAA
Species	Human
Gene Type	protein-coding
Description	protein kinase, AMP-activated, alpha 2 catalytic subunit
Other Description	5'-AMP-activated protein kinase catalytic subunit alpha-2|5'-AMP-activated protein kinase, catalytic alpha-2 chain|ACACA kinase|AMP-activated protein kinase alpha-2 subunit variant 2|AMP-activated protein kinase alpha-2 subunit variant 3|AMPK alpha 2|AMPK subunit alpha-2|AMPK-alpha-2 chain|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase
Swissprots	Q9H1E8 Q9UD43 P54646
Accessions	AAB32732 EAX06650 P54646 AI732856 AK314011 BAG36722 AL596521 AL710110 BC043195 BC069680 AAH69680 BC069740 AAH69740 BC069823 AAH69823 BM979925 CB985850 CF552084 DA710012 EF056019 ABK30810 FJ200485 ACO54882 FJ200486 ACO54883 HQ628625 AER93375 U06454 AAA64745 NM_006252 NP_006243
Function	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters.
Top Pathways	Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human AMPK alpha 2 + AMPK beta 1 +AMPK gamma 3 full length protein - ab184881 from Abcam Category Protein Prices $697.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human AMPK alpha 2 full length protein - ab126916 from Abcam Category Protein Prices $410.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human AMPK alpha 2 full length protein - ab159188 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human AMPK alpha 2 peptide - ab97990 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human AMPK alpha 2 protein fragment - ab159189 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

PRKAA2 / AMPK Alpha 2 Antibody Blocking Peptide - LS-E544 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAA2 / AMPK Alpha 2 Antibody Blocking Peptide - LS-E20626 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAA2 / AMPK Alpha 2 Antibody Blocking Peptide - LS-E27450 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAA2 / AMPK Alpha 2 Antibody Blocking Peptide - LS-E8763 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AMPK alpha 2 Protein - H00005563-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human AMPK alpha 2 Protein - H00005563-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AMPK alpha 2 Peptide - P2372 from Novus Biologicals Category Peptide Species Human

PRKAA2-Thr172-Antibody-Center-Blocking-peptide - BP10846a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AMPK-alpha2-Antibody-C-term-Blocking-Peptide - BP7203a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AMPK alpha 2 blocking peptide - GTX88046-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Human AMPK protein - orb138174 from Biorbyt Category Protein Prices $893.00, $1,114.00 Sizes 20 μg, 50 μg Source Baculovirus-Insect Cells Species Human

Human AMPK protein - orb138172 from Biorbyt Category Protein Prices $527.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

Human AMPK protein - orb138173 from Biorbyt Category Protein Prices $612.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human AMPK protein - orb138171 from Biorbyt Category Protein Prices $527.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

PRKAA1 protein (His tag) - 80R-4119 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

PRKAA2 Blocking Peptide - 33R-1630 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AMPK alpha 2 Peptide - AC21-2274-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PRKAA2 - H00005563-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

PRKAA2 - H00005563-P01-10 from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Species Human

PRKAA2 - H00005563-P01-25 from Acris Antibodies Category Protein Prices $460.00 Sizes 25 µg Species Human

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