| Gene Symbol |
PRKAA2
|
| Entrez Gene |
5563
|
| Alt Symbol |
AMPK, AMPK2, AMPKa2, PRKAA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, AMP-activated, alpha 2 catalytic subunit
|
| Other Description |
5'-AMP-activated protein kinase catalytic subunit alpha-2|5'-AMP-activated protein kinase, catalytic alpha-2 chain|ACACA kinase|AMP-activated protein kinase alpha-2 subunit variant 2|AMP-activated protein kinase alpha-2 subunit variant 3|AMPK alpha 2|AMPK subunit alpha-2|AMPK-alpha-2 chain|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase
|
| Swissprots |
Q9H1E8 Q9UD43 P54646
|
| Accessions |
AAB32732 EAX06650 P54646 AI732856 AK314011 BAG36722 AL596521 AL710110 BC043195 BC069680 AAH69680 BC069740 AAH69740 BC069823 AAH69823 BM979925 CB985850 CF552084 DA710012 EF056019 ABK30810 FJ200485 ACO54882 FJ200486 ACO54883 HQ628625 AER93375 U06454 AAA64745 NM_006252 NP_006243
|
| Function |
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters.
|
| Top Pathways |
Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway
|
![Western Blot: AMPK alpha 2 Overexpression Lysate (Adult Normal) [NBP2-10422] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AMPK alpha 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1087_AMPK%2520alpha%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10422-img0001.jpg)