PRKAA2

Gene Symbol	PRKAA2
Entrez Gene	5563
Alt Symbol	AMPK, AMPK2, AMPKa2, PRKAA
Species	Human
Gene Type	protein-coding
Description	protein kinase, AMP-activated, alpha 2 catalytic subunit
Other Description	5'-AMP-activated protein kinase catalytic subunit alpha-2|5'-AMP-activated protein kinase, catalytic alpha-2 chain|ACACA kinase|AMP-activated protein kinase alpha-2 subunit variant 2|AMP-activated protein kinase alpha-2 subunit variant 3|AMPK alpha 2|AMPK subunit alpha-2|AMPK-alpha-2 chain|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase
Swissprots	Q9H1E8 Q9UD43 P54646
Accessions	AAB32732 EAX06650 P54646 AI732856 AK314011 BAG36722 AL596521 AL710110 BC043195 BC069680 AAH69680 BC069740 AAH69740 BC069823 AAH69823 BM979925 CB985850 CF552084 DA710012 EF056019 ABK30810 FJ200485 ACO54882 FJ200486 ACO54883 HQ628625 AER93375 U06454 AAA64745 NM_006252 NP_006243
Function	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters.
Top Pathways	Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PRKAA2 gene - orb90979 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-PRKAA2-cDNA-Clone - DC08821 from Abgent, a WuXi AppTec company Prices $745.20 Sizes 10 µg Species Human Accession BC069680

Human PRKAA2 ORF clone(NM_006252.3) - CDCL185814 from Creative Biomart Species Human Accession NM_006252.3

Human PRKAA2/AMPK Gene ORF cDNA clone in cloning vector - HG10394-M from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10394-ACG from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, N-His tag - HG10394-NH from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, C-His tag - HG10394-CH from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid - HG10394-UT from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10394-ANG from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10394-NF from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10394-NM from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, C-HA tag - HG10394-CY from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10394-CF from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, N-HA tag - HG10394-NY from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10394-CM from Sino Biological Species Human

Human PRKAA2 / AMPK Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10394-M-F from Sino Biological Species Human Accession NM_006252.3

Human PRKAA2 / AMPK Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10394-M-N from Sino Biological Species Human Accession NM_006252.3

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10394-ACR from Sino Biological Species Human

Human PRKAA2/AMPK Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10394-ANR from Sino Biological Species Human

Human PRKAA2 ORF clone(NM_006252.3) - CDCL185814 from Creative biogene Species Human

Human PRKAA2 ORF Clone (BC069680) - CDCS412626 from Creative biogene Species Human Accession P54646

Search more