Gene Symbol | PON1 |
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Entrez Gene | 5444 |
Alt Symbol | ESA, MVCD5, PON |
Species | Human |
Gene Type | protein-coding |
Description | paraoxonase 1 |
Other Description | A-esterase 1|K-45|PON 1|aromatic esterase 1|arylesterase 1|arylesterase B-type|esterase A|paraoxonase B-type|serum aryldiakylphosphatase|serum aryldialkylphosphatase 1|serum paraoxonase/arylesterase 1 |
Swissprots | Q16052 B2RA40 Q9UCB1 P27169 Q6B0J6 |
Accessions | AAB25717 AAB27899 AAB41835 AAC35293 AAD02576 AAL04502 AAL04503 AAL04504 AAM97935 ACA53454 AEO20077 EAL24133 EAW76771 P27169 AK314027 BAG36737 AV652982 BC074719 AAH74719 BJ993711 CB122285 D84371 BAA12327 M63012 AAB59538 M63013 AAA60142 M63014 AAA60143 S64615 AAB27714 U53784 AAA97957 Z70723 CAA94728 NM_000446 NP_000437 |
Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. {ECO:0000269|PubMed:10479665, ECO:0000269|PubMed:15772423}. |
Subcellular Location | Secreted, extracellular space. |
Tissue Specificity | Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. {ECO:0000269|PubMed:8292612, ECO:0000269|PubMed:8382160}. |
Human PON1 / ESA ELISA Kit (Sandwich ELISA) - LS-F2850 from LifeSpan Bioscience
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Rat PON1 / ESA ELISA Kit (Sandwich ELISA) - LS-F6365 from LifeSpan Bioscience
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Human PON1 / ESA ELISA Kit (Sandwich ELISA) - LS-F4609 from LifeSpan Bioscience
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Mouse PON1 / ESA ELISA Kit (Sandwich ELISA) - LS-F7048 from LifeSpan Bioscience
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Human PON1 / ESA ELISA Kit (Sandwich ELISA) - LS-F12362 from LifeSpan Bioscience
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Human Total PON1 DuoSet IC ELISA - DYC5816-2 from R&D Systems
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Human Total PON1 DuoSet IC, 5 Plate - DYC5816-5 from R&D Systems
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Human Paraoxonase 1 ELISA Kit - abx152642 from Abbexa
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Human PON1 ELISA Kit - abx056311 from Abbexa
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ESA (Epithelial Specific Antigen), Human, ELISA Kit - E-EL-H1879 from ARP American Research Products
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Paraoxonase 1 (PON1), Human, ELISA Kit - SEA243Hu from ARP American Research Products
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Paraoxonase 1, Human, ELISA Kit - E01P0698 from ARP American Research Products
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Paraoxonase, PON, Human, ELISA Kit - CSB-E09484h from ARP American Research Products
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Paraoxonase 1, PON1, Human, ELISA Kit - E-EL-H2298 from ARP American Research Products
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Serum paraoxonase/arylesterase 1, PON1, Human, ELISA Kit - E0243h from ARP American Research Products
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ESA (Epithelial Specific Antigen), Rabbit, ELISA Kit - E-EL-RB0698 from ARP American Research Products
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Paraoxonase 1, PON1, Rabbit, ELISA Kit - E-EL-RB0694 from ARP American Research Products
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ESA (Epithelial Specific Antigen), Chicken, ELISA Kit - E-EL-Ch1092 from ARP American Research Products
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Paraoxonase 1, PON1, Chicken, ELISA Kit - E-EL-Ch1891 from ARP American Research Products
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ESA (Epithelial Specific Antigen), Pig, ELISA Kit - E-EL-P1052 from ARP American Research Products
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Paraoxonase 1, PON1, Porcine, ELISA Kit - E-EL-P0559 from ARP American Research Products
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ESA (Epithelial Specific Antigen), Guinea Pig, ELISA Kit - E-EL-GP0020 from ARP American Research Products
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Paraoxonase 1, PON1, Guinea Pig, ELISA Kit - E-EL-GP0287 from ARP American Research Products
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ESA (Epithelial Specific Antigen), Monkey, ELISA Kit - E-EL-MK1619 from ARP American Research Products
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Paraoxonase 1, PON1, Monkey, ELISA Kit - E-EL-MK1395 from ARP American Research Products
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