| Gene Symbol |
PON1
|
| Entrez Gene |
5444
|
| Alt Symbol |
ESA, MVCD5, PON
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
paraoxonase 1
|
| Other Description |
A-esterase 1|K-45|PON 1|aromatic esterase 1|arylesterase 1|arylesterase B-type|esterase A|paraoxonase B-type|serum aryldiakylphosphatase|serum aryldialkylphosphatase 1|serum paraoxonase/arylesterase 1
|
| Swissprots |
Q16052 B2RA40 Q9UCB1 P27169 Q6B0J6
|
| Accessions |
AAB25717 AAB27899 AAB41835 AAC35293 AAD02576 AAL04502 AAL04503 AAL04504 AAM97935 ACA53454 AEO20077 EAL24133 EAW76771 P27169 AK314027 BAG36737 AV652982 BC074719 AAH74719 BJ993711 CB122285 D84371 BAA12327 M63012 AAB59538 M63013 AAA60142 M63014 AAA60143 S64615 AAB27714 U53784 AAA97957 Z70723 CAA94728 NM_000446 NP_000437
|
| Function |
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. {ECO:0000269|PubMed:10479665, ECO:0000269|PubMed:15772423}.
|
| Subcellular Location |
Secreted, extracellular space.
|
| Tissue Specificity |
Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. {ECO:0000269|PubMed:8292612, ECO:0000269|PubMed:8382160}.
|
![Western Blot: PON1 Overexpression Lysate (Adult Normal) [NBL1-14604] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PON1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/893_PON1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14604-img0002.jpg)