| Gene Symbol |
UBE2M
|
| Entrez Gene |
9040
|
| Alt Symbol |
UBC-RS2, UBC12, hUbc12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2M
|
| Other Description |
NEDD8 carrier protein|NEDD8 protein ligase|NEDD8-conjugating enzyme Ubc12|ubiquitin carrier protein M|ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)|ubiquitin-protein ligase M|yeast UBC12 homolog
|
| Swissprots |
P61081
|
| Accessions |
CDM22105 EAW72612 EAW72613 P61081 AB012191 BAA33145 AF075599 AAC26141 AL569047 BC058924 AAH58924 BM559596 BM798750 BT006754 AAP35400 BU508830 BX342697 NM_003969 NP_003960
|
| Function |
Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:15361859}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|