CD47

Gene Symbol	CD47
Entrez Gene	961
Alt Symbol	IAP, MER6, OA3
Species	Human
Gene Type	protein-coding
Description	CD47 molecule
Other Description	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)|CD47 glycoprotein|Rh-related antigen|antigen identified by monoclonal antibody 1D8|antigenic surface determinant protein OA3|integrin associated protein|integrin-associated protein|integrin-associated signal transducer|leukocyte surface antigen CD47
Swissprots	D3DN59 Q08722 Q53Y71 Q96A60 A8K198
Accessions	AAQ11189 EAW79732 EAW79733 EAW79734 Q08722 AI701980 AK096670 AK124152 AK289813 BAF82502 AL832675 BC010016 AAH10016 BC012884 AAH12884 BC037306 AAH37306 BC042889 BC045593 BC053959 BI753986 BT006907 AAP35553 BX640889 CB995865 DQ890756 ABM81682 DQ891811 ABM82737 DQ893920 ABM84846 LN680437 CEJ95640 X69398 CAA49196 Z25521 CAA80977 XM_005247908 XP_005247965 XM_005247909 XP_005247966 XR_241521 XR_241522 XR_924218 XR_924219 XR_924220 NM_001777 NP_001768 NM_198793 NP_942088 NM_001025079 NM_001025080
Function	Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. {ECO:0000250, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:7691831}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:7691831}; Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
Tissue Specificity	Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
Top Pathways	ECM-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD47 protein fragment - ab174029 from Abcam Category Protein Prices $400.00 Sizes 50 µg Source HEK 293 cells Species Human

Human CD47 protein fragment - ab151372 from Abcam Category Protein Prices $188.00 Sizes 10 µg Species Human

Human CD47 protein fragment - ab185582 from Abcam Category Protein Prices $588.00 Sizes 50 µg Source E. coli Species Human

Human CD47 protein fragment - ab126004 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

CD47 Antibody Blocking Peptide - LS-E23085 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD47 Antibody Blocking Peptide - LS-E9960 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD47 Recombinant Protein - H00000961-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human CD47 Protein - H00000961-G01 from Novus Biologicals Category Protein Prices $539.00 Sizes 2 µg Source Wheat Germ Species Human

CD47-Antibody-C-term-Blocking-Peptide - BP9137b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human CD47 Fc Chimera, CF - 4670-CD-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human CD47 R protein - orb163535 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

Human CD47 protein - orb49283 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

CD47 - H00000961-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD47 - H00000961-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CD47, Human, Recombinant - 19-C321 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

CD47, Human, Recombinant - 19-CG18 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source HEK293 Species Human

CD47 Recombinant Protein - 96-134 from ProSci Category Protein Prices $400.00 Sizes 100 µg Source HEK293 cells Species Human

CD47 Recombinant Protein - 96-132 from ProSci Category Protein Prices $400.00 Sizes 50 µg Source HEK293 cells Species Human

CD47 fusion protein - ag14417 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

CD47 fusion protein - ag14132 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CD47 Protein - BP001713-C321 from Syd Labs Category Protein Prices $98.00, $264.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human CD47, Fc tagged - CD47-7889H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human CD47, His-tagged - CD47-7862H from Creative Biomart Category Protein Source HEK293 Cells Species Human

Recombinant Integrin Associated Protein (IAP) - RPB014Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Integrin Associated Protein (IAP) - RPB014Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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