| Gene Symbol |
EXT2
|
| Entrez Gene |
2132
|
| Alt Symbol |
SOTV
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exostosin glycosyltransferase 2
|
| Other Description |
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|exostosin-2|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|multiple exostoses protein 2|putative tumor suppressor protein EXT2
|
| Swissprots |
O15288 J3KPT2 C9JU51 Q93063 B2R5Z6
|
| Accessions |
AAC51219 EAW68067 EAW68068 EAW68069 EAW68070 EAW68071 Q93063 AK296713 BAH12417 AK309459 AK312375 BAG35293 BC010058 AAH10058 BC013050 BC068545 AAH68545 BE348865 BM997250 BX648142 DA738392 JF432315 ADZ15532 U62740 AAB07008 U64511 AAC50764 U72263 AAB62718 XM_011519950 XP_011518252 XM_011519951 XP_011518253 NM_000401 NP_000392 NM_001178083 NP_001171554 NM_207122 NP_997005
|
| Function |
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|
![Western Blot: exostosin 2 Overexpression Lysate (Adult Normal) [NBL1-10392] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for exostosin 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9610_exostosin%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10392-img0002.jpg)