EXT2

Gene Symbol	EXT2
Entrez Gene	2132
Alt Symbol	SOTV
Species	Human
Gene Type	protein-coding
Description	exostosin glycosyltransferase 2
Other Description	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|exostosin-2|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|multiple exostoses protein 2|putative tumor suppressor protein EXT2
Swissprots	O15288 J3KPT2 C9JU51 Q93063 B2R5Z6
Accessions	AAC51219 EAW68067 EAW68068 EAW68069 EAW68070 EAW68071 Q93063 AK296713 BAH12417 AK309459 AK312375 BAG35293 BC010058 AAH10058 BC013050 BC068545 AAH68545 BE348865 BM997250 BX648142 DA738392 JF432315 ADZ15532 U62740 AAB07008 U64511 AAC50764 U72263 AAB62718 XM_011519950 XP_011518252 XM_011519951 XP_011518253 NM_000401 NP_000392 NM_001178083 NP_001171554 NM_207122 NP_997005
Function	Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Tissue Specificity	Ubiquitous.
Top Pathways	Glycosaminoglycan biosynthesis - heparan sulfate / heparin

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ext2 full length protein - ab158395 from Abcam Category Protein Source Wheat germ Species Human

Human Ext2 protein fragment - ab158396 from Abcam Category Protein Source Wheat germ Species Human

EXT2-Antibody-C-term-Blocking-Peptide - BP14426b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXT2-Antibody-Center-Blocking-Peptide - BP9401c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXT2 blocking peptide - GTX88151-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

EXT2 Peptide - AC21-1905-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Exostosin-2 - H00002132-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Exostosin-2 - H00002132-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Exostosin-2 - H00002132-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Exostosin-2 - H00002132-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EXT2 Peptide - 42-487P from ProSci Category Peptide

EXT2 fusion protein - ag1748 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human EXT2, GST-tagged - EXT2-12604H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exostosin-2(EXT2) - CSB-YP849974HU CSB-EP849974HU CSB-BP849974HU CSB-MP849974HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXT2, Peptide - MBS427184 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

Ext2 Recombinant Protein Antigen - NBP2-58869PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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