EXT2

Gene Symbol EXT2
Entrez Gene 2132
Alt Symbol SOTV
Species Human
Gene Type protein-coding
Description exostosin glycosyltransferase 2
Other Description N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|exostosin-2|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|multiple exostoses protein 2|putative tumor suppressor protein EXT2
Swissprots O15288 J3KPT2 C9JU51 Q93063 B2R5Z6
Accessions AAC51219 EAW68067 EAW68068 EAW68069 EAW68070 EAW68071 Q93063 AK296713 BAH12417 AK309459 AK312375 BAG35293 BC010058 AAH10058 BC013050 BC068545 AAH68545 BE348865 BM997250 BX648142 DA738392 JF432315 ADZ15532 U62740 AAB07008 U64511 AAC50764 U72263 AAB62718 XM_011519950 XP_011518252 XM_011519951 XP_011518253 NM_000401 NP_000392 NM_001178083 NP_001171554 NM_207122 NP_997005
Function Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Tissue Specificity Ubiquitous.
Top Pathways Glycosaminoglycan biosynthesis - heparan sulfate / heparin

EXT2 CRISPR/Cas9 KO Plasmid (h) - sc-406286 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT2 HDR Plasmid (h) - sc-406286-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT2 Double Nickase Plasmid (h) - sc-406286-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT2 Double Nickase Plasmid (h2) - sc-406286-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT2 CRISPR Activation Plasmid (h) - sc-406286-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT2 CRISPR Activation Plasmid (h2) - sc-406286-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT2 Lentiviral Activation Particles (h) - sc-406286-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT2 Lentiviral Activation Particles (h2) - sc-406286-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT2 siRNA (h) - sc-106830 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXT2 shRNA Plasmid (h) - sc-106830-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXT2 shRNA (h) Lentiviral Particles - sc-106830-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU134021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8057 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8057 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12521 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12521

EXT2 siRNA (Human) - CRH1483 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EXT2 - MBS8209420 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human EXT2 siRNA - orb261985 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EXT2 shRNA Plasmid (Human) - CHH1483 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EXT2 miRNA 3'UTR clone - MiUTR3H-09846 from Creative biogene

Species Reactivities Human

EXT2 miRNA 3'UTR clone - MiUTR3H-09847 from Creative biogene

Species Reactivities Human
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