| Gene Symbol |
ABHD5
|
| Entrez Gene |
51099
|
| Alt Symbol |
CDS, CGI58, IECN2, NCIE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
abhydrolase domain containing 5
|
| Other Description |
1-acylglycerol-3-phosphate O-acyltransferase ABHD5|abhydrolase domain-containing protein 5|lipid droplet-binding protein CGI-58
|
| Swissprots |
B2R9K0 Q8WTS1 Q9Y369
|
| Accessions |
AEB53058 AEB53059 AEB53060 AEB53061 CAD12731 EAW64699 Q8WTS1 AF007132 AF151816 AAD34053 AK313811 BAG36547 BC021958 AAH21958 BG721387 DQ891175 ABM82101 DQ894357 ABM85283 XM_011533779 XP_011532081 XM_011533780 XP_011532082 XR_940447 NM_016006 NP_057090
|
| Function |
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. {ECO:0000269|PubMed:16679289, ECO:0000269|PubMed:18606822, ECO:0000269|PubMed:18832586}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18832586}. Lipid droplet {ECO:0000250}. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level). {ECO:0000269|PubMed:11590543, ECO:0000269|PubMed:18832586}.
|