Gene Symbol | ABHD5 |
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Entrez Gene | 51099 |
Alt Symbol | CDS, CGI58, IECN2, NCIE2 |
Species | Human |
Gene Type | protein-coding |
Description | abhydrolase domain containing 5 |
Other Description | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5|abhydrolase domain-containing protein 5|lipid droplet-binding protein CGI-58 |
Swissprots | B2R9K0 Q8WTS1 Q9Y369 |
Accessions | AEB53058 AEB53059 AEB53060 AEB53061 CAD12731 EAW64699 Q8WTS1 AF007132 AF151816 AAD34053 AK313811 BAG36547 BC021958 AAH21958 BG721387 DQ891175 ABM82101 DQ894357 ABM85283 XM_011533779 XP_011532081 XM_011533780 XP_011532082 XR_940447 NM_016006 NP_057090 |
Function | Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. {ECO:0000269|PubMed:16679289, ECO:0000269|PubMed:18606822, ECO:0000269|PubMed:18832586}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18832586}. Lipid droplet {ECO:0000250}. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity). {ECO:0000250}. |
Tissue Specificity | Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level). {ECO:0000269|PubMed:11590543, ECO:0000269|PubMed:18832586}. |
ABHD5 CRISPR/Cas9 KO Plasmid (h) - sc-402273 from Santa Cruz Biotechnology
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ABHD5 HDR Plasmid (h) - sc-402273-HDR from Santa Cruz Biotechnology
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ABHD5 Double Nickase Plasmid (h) - sc-402273-NIC from Santa Cruz Biotechnology
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ABHD5 Double Nickase Plasmid (h2) - sc-402273-NIC-2 from Santa Cruz Biotechnology
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ABHD5 CRISPR Activation Plasmid (h) - sc-402273-ACT from Santa Cruz Biotechnology
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ABHD5 CRISPR Activation Plasmid (h2) - sc-402273-ACT-2 from Santa Cruz Biotechnology
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ABHD5 Lentiviral Activation Particles (h) - sc-402273-LAC from Santa Cruz Biotechnology
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ABHD5 Lentiviral Activation Particles (h2) - sc-402273-LAC-2 from Santa Cruz Biotechnology
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ABHD5 siRNA (h) - sc-78146 from Santa Cruz Biotechnology
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ABHD5 shRNA Plasmid (h) - sc-78146-SH from Santa Cruz Biotechnology
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ABHD5 shRNA (h) Lentiviral Particles - sc-78146-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU019081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2666 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2666 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02666 from Sigma-Aldrich
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ABHD5 siRNA (Human) - CRH9520 from Cohesion Biosciences
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Abhd5 RNAi - H00051099-R01 from Novus Biologicals
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ABHD5 - MBS8219293 from MyBioSource
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shRNA set against Human ABHD5 (NM_016006.4) - SHH229538 from Creative biogene
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Human ABHD5 siRNA - orb270022 from Biorbyt
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ABHD5 shRNA Plasmid (Human) - CHH9520 from Cohesion Biosciences
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ABHD5 miRNA 3'UTR clone - MiUTR4H-TG00050 from Creative biogene
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