Gene Symbol | ABHD5 |
---|---|
Entrez Gene | 51099 |
Alt Symbol | CDS, CGI58, IECN2, NCIE2 |
Species | Human |
Gene Type | protein-coding |
Description | abhydrolase domain containing 5 |
Other Description | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5|abhydrolase domain-containing protein 5|lipid droplet-binding protein CGI-58 |
Swissprots | B2R9K0 Q8WTS1 Q9Y369 |
Accessions | AEB53058 AEB53059 AEB53060 AEB53061 CAD12731 EAW64699 Q8WTS1 AF007132 AF151816 AAD34053 AK313811 BAG36547 BC021958 AAH21958 BG721387 DQ891175 ABM82101 DQ894357 ABM85283 XM_011533779 XP_011532081 XM_011533780 XP_011532082 XR_940447 NM_016006 NP_057090 |
Function | Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. {ECO:0000269|PubMed:16679289, ECO:0000269|PubMed:18606822, ECO:0000269|PubMed:18832586}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18832586}. Lipid droplet {ECO:0000250}. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity). {ECO:0000250}. |
Tissue Specificity | Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level). {ECO:0000269|PubMed:11590543, ECO:0000269|PubMed:18832586}. |