| Gene Symbol | DNASE2B |
|---|---|
| Entrez Gene | 58511 |
| Alt Symbol | DLAD |
| Species | Human |
| Gene Type | protein-coding |
| Description | deoxyribonuclease II beta |
| Other Description | DNase II beta|DNase II-like acid DNase|DNase2-like acid DNase|deoxyribonuclease-2-beta|endonuclease DLAD|lysosomal DNase II |
| Swissprots | Q5VXD0 Q8WZ80 Q5VXD1 Q9NQW3 Q8WZ79 |
| Accessions | AAL34449 EAW73238 EAW73239 Q8WZ79 AF274571 AAF76893 AF333389 AAL34448 BC065182 BC080621 AAH80621 BC126136 AAI26137 BC126138 AAI26139 HQ258219 ADR82973 XM_011541878 XP_011540180 NM_021233 NP_067056 NM_058248 NP_490649 |
| Function | Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. {ECO:0000269|PubMed:11700027, ECO:0000269|PubMed:12944971}. |
| Subcellular Location | Lysosome {ECO:0000305}. |
| Tissue Specificity | Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific. {ECO:0000269|PubMed:11376952, ECO:0000269|PubMed:11700027, ECO:0000269|PubMed:12944971}. |
| Top Pathways | Lysosome |
Deoxyribonuclease-2-beta, DNASE2B, ELISA Kit - MBS9306385 from MyBioSource
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Deoxyribonuclease-2-beta, DNASE2B, ELISA Kit - MBS9307212 from MyBioSource
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Deoxyribonuclease-2-beta, DNASE2B, ELISA Kit - MBS9306229 from MyBioSource
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Human DNASE2B ELISA Kit - E011708 from Biobool
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Deoxyribonuclease-2-beta, ELISA Kit - MBS285687 from MyBioSource
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