DNASE2B

Gene Symbol	DNASE2B
Entrez Gene	58511
Alt Symbol	DLAD
Species	Human
Gene Type	protein-coding
Description	deoxyribonuclease II beta
Other Description	DNase II beta|DNase II-like acid DNase|DNase2-like acid DNase|deoxyribonuclease-2-beta|endonuclease DLAD|lysosomal DNase II
Swissprots	Q5VXD0 Q8WZ80 Q5VXD1 Q9NQW3 Q8WZ79
Accessions	AAL34449 EAW73238 EAW73239 Q8WZ79 AF274571 AAF76893 AF333389 AAL34448 BC065182 BC080621 AAH80621 BC126136 AAI26137 BC126138 AAI26139 HQ258219 ADR82973 XM_011541878 XP_011540180 NM_021233 NP_067056 NM_058248 NP_490649
Function	Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. {ECO:0000269|PubMed:11700027, ECO:0000269|PubMed:12944971}.
Subcellular Location	Lysosome {ECO:0000305}.
Tissue Specificity	Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific. {ECO:0000269|PubMed:11376952, ECO:0000269|PubMed:11700027, ECO:0000269|PubMed:12944971}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DNASE2B CRISPR/Cas9 KO Plasmid (h) - sc-412919 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DNASE2B HDR Plasmid (h) - sc-412919-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNASE2B Double Nickase Plasmid (h) - sc-412919-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNASE2B Double Nickase Plasmid (h2) - sc-412919-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNASE2B CRISPR Activation Plasmid (h) - sc-412919-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DNASE2B CRISPR Activation Plasmid (h2) - sc-412919-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DNASE2B Lentiviral Activation Particles (h) - sc-412919-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNASE2B Lentiviral Activation Particles (h2) - sc-412919-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DNASE2B siRNA (h) - sc-88084 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNASE2B shRNA Plasmid (h) - sc-88084-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNASE2B shRNA (h) Lentiviral Particles - sc-88084-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DNASE2B RNAi - H00058511-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN7393 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7393 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02065 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02065

DNASE2B siRNA (Human) - CRJ1738 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DNASE2B RNAi - H00058511-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

DNASE2B - MBS8216223 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Dnase2b (NM_021233.2) - SHH279853 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DNASE2B(NM_058248.1) - SHH011747 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DNASE2B(NM_021233.2) - SHH011801 from Creative biogene Category siRNA Species Reactivities Human

DNASE2B shRNA Plasmid (Human) - CHJ1738 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

DNASE2B miRNA 3'UTR clone - MiUTR1H-02935 from Creative biogene Species Reactivities Human

DNASE2B miRNA 3'UTR clone - MiUTR4H-TG02810 from Creative biogene Species Reactivities Human

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