| Gene Symbol |
DNASE2B
|
| Entrez Gene |
58511
|
| Alt Symbol |
DLAD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
deoxyribonuclease II beta
|
| Other Description |
DNase II beta|DNase II-like acid DNase|DNase2-like acid DNase|deoxyribonuclease-2-beta|endonuclease DLAD|lysosomal DNase II
|
| Swissprots |
Q5VXD0 Q8WZ80 Q5VXD1 Q9NQW3 Q8WZ79
|
| Accessions |
AAL34449 EAW73238 EAW73239 Q8WZ79 AF274571 AAF76893 AF333389 AAL34448 BC065182 BC080621 AAH80621 BC126136 AAI26137 BC126138 AAI26139 HQ258219 ADR82973 XM_011541878 XP_011540180 NM_021233 NP_067056 NM_058248 NP_490649
|
| Function |
Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. {ECO:0000269|PubMed:11700027, ECO:0000269|PubMed:12944971}.
|
| Subcellular Location |
Lysosome {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific. {ECO:0000269|PubMed:11376952, ECO:0000269|PubMed:11700027, ECO:0000269|PubMed:12944971}.
|
| Top Pathways |
Lysosome
|
![Western Blot: DNASE2B Overexpression Lysate (Adult Normal) [NBP2-06536] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNASE2B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4754_DNASE2B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06536-img0001.jpg)