| Gene Symbol |
MUS81
|
| Entrez Gene |
80198
|
| Alt Symbol |
SLX3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MUS81 structure-specific endonuclease subunit
|
| Other Description |
MUS81 endonuclease homolog|SLX3 structure-specific endonuclease subunit homolog|crossover junction endonuclease MUS81
|
| Swissprots |
Q9H7D9 Q96NY9
|
| Accessions |
EAW74453 EAW74454 Q96NY9 AF425646 AAL28065 AK024665 BAB14953 AK095326 AK126820 BAG54375 AK223564 BAD97284 AL353934 CAH56369 BC009999 AAH09999 BI816797 DA449863 XM_005274307 XP_005274364 XM_011545269 XP_011543571 XM_011545270 XP_011543572 XM_011545271 XP_011543573 XR_247212 XR_950067 NM_025128 NP_079404
|
| Function |
Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:14638871, ECO:0000269|PubMed:15805243}. Note=Recruited to foci of DNA damage in S-phase cells.
|
| Tissue Specificity |
Widely expressed.
|
| Top Pathways |
Homologous recombination, Fanconi anemia pathway
|
![Western Blot: Mus81 Overexpression Lysate (Adult Normal) [NBL1-13396] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Mus81.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8190_Mus81%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-13396-img0002.jpg)