MUS81

Gene Symbol MUS81
Entrez Gene 80198
Alt Symbol SLX3
Species Human
Gene Type protein-coding
Description MUS81 structure-specific endonuclease subunit
Other Description MUS81 endonuclease homolog|SLX3 structure-specific endonuclease subunit homolog|crossover junction endonuclease MUS81
Swissprots Q9H7D9 Q96NY9
Accessions EAW74453 EAW74454 Q96NY9 AF425646 AAL28065 AK024665 BAB14953 AK095326 AK126820 BAG54375 AK223564 BAD97284 AL353934 CAH56369 BC009999 AAH09999 BI816797 DA449863 XM_005274307 XP_005274364 XM_011545269 XP_011543571 XM_011545270 XP_011543572 XM_011545271 XP_011543573 XR_247212 XR_950067 NM_025128 NP_079404
Function Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:14638871, ECO:0000269|PubMed:15805243}. Note=Recruited to foci of DNA damage in S-phase cells.
Tissue Specificity Widely expressed.
Top Pathways Homologous recombination, Fanconi anemia pathway

Human Mus81 full length protein - ab153520 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153520 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human Mus81 protein fragment - ab153521 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153521 on a 12.5% SDS-PAGE stained with Coomassie Blue.

MUS81 Antibody Blocking Peptide - LS-E22450 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

MUS81 Antibody Blocking Peptide - LS-E22451 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Mus81 Recombinant Protein - H00080198-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Species Human

Recombinant Human Mus81 Protein - H00080198-Q01 from Novus Biologicals

Category Protein
Prices $250.00
Sizes 2 µg
Source Wheat Germ
Species Human

MUS81 Blocking Peptide - 33R-3252 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

MUS81 Blocking Peptide - 33R-7043 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

MUS81 - H00080198-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

MUS81 - H00080198-Q01 from Acris Antibodies

Category Protein
Prices $340.00
Sizes 2 µg
Species Human

MUS81 - H00080198-Q01-10 from Acris Antibodies

Category Protein
Prices $370.00
Sizes 10 µg
Source in vitro transl.
Species Human

MUS81 - H00080198-Q01-25 from Acris Antibodies

Category Protein
Prices $520.00
Sizes 25 µg
Source in vitro transl.
Species Human

MUS81 fusion protein - ag1476 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Crossover junction endonuclease MUS81(MUS81) - CSB-YP836272HU CSB-EP836272HU CSB-BP836272HU CSB-MP836272HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

MUS81 Protein - abx164942 from Abbexa

Category Protein
Species Human, Mouse, Rat

MUS81 - TP303373 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
MUS81

Mus81 Recombinant Protein Antigen - NBP2-32474PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

MUS81 Peptide, Human - M34GP09945H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Crossover junction endonuclease MUS81 (MUS81), Recombinant Protein - MBS1380689 from MyBioSource

Category Protein
Prices $1,345.00, $1,345.00, $1,565.00, $1,565.00, $2,230.00, $2,230.00, $2,695.00, $2,695.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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