MUS81

Gene Symbol MUS81
Entrez Gene 80198
Alt Symbol SLX3
Species Human
Gene Type protein-coding
Description MUS81 structure-specific endonuclease subunit
Other Description MUS81 endonuclease homolog|SLX3 structure-specific endonuclease subunit homolog|crossover junction endonuclease MUS81
Swissprots Q9H7D9 Q96NY9
Accessions EAW74453 EAW74454 Q96NY9 AF425646 AAL28065 AK024665 BAB14953 AK095326 AK126820 BAG54375 AK223564 BAD97284 AL353934 CAH56369 BC009999 AAH09999 BI816797 DA449863 XM_005274307 XP_005274364 XM_011545269 XP_011543571 XM_011545270 XP_011543572 XM_011545271 XP_011543573 XR_247212 XR_950067 NM_025128 NP_079404
Function Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:14638871, ECO:0000269|PubMed:15805243}. Note=Recruited to foci of DNA damage in S-phase cells.
Tissue Specificity Widely expressed.
Top Pathways Homologous recombination, Fanconi anemia pathway

MUS81 CRISPR/Cas9 KO Plasmid (h) - sc-402664 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MUS81 HDR Plasmid (h) - sc-402664-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MUS81 Double Nickase Plasmid (h) - sc-402664-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MUS81 Double Nickase Plasmid (h2) - sc-402664-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MUS81 CRISPR Activation Plasmid (h) - sc-402664-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MUS81 CRISPR Activation Plasmid (h2) - sc-402664-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MUS81 Lentiviral Activation Particles (h) - sc-402664-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MUS81 Lentiviral Activation Particles (h2) - sc-402664-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MUS81 siRNA (h) - sc-40751 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MUS81 shRNA Plasmid (h) - sc-40751-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MUS81 shRNA (h) Lentiviral Particles - sc-40751-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU020611 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14769 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1466 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1466 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14769 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12076 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12076

MUS81 siRNA (Human) - CRJ2795 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Mus81 RNAi - H00080198-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MUS81 (NM_025128.4) - SHH347172 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MUS81(NM_025128.4) - SHH208973 from Creative biogene

Category siRNA
Species Reactivities Human

Human MUS81 siRNA - orb273296 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MUS81 shRNA Plasmid (Human) - CHJ2795 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MUS81 miRNA 3'UTR clone - MiUTR1H-06533 from Creative biogene

Species Reactivities Human
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