MUS81

Gene Symbol	MUS81
Entrez Gene	80198
Alt Symbol	SLX3
Species	Human
Gene Type	protein-coding
Description	MUS81 structure-specific endonuclease subunit
Other Description	MUS81 endonuclease homolog|SLX3 structure-specific endonuclease subunit homolog|crossover junction endonuclease MUS81
Swissprots	Q9H7D9 Q96NY9
Accessions	EAW74453 EAW74454 Q96NY9 AF425646 AAL28065 AK024665 BAB14953 AK095326 AK126820 BAG54375 AK223564 BAD97284 AL353934 CAH56369 BC009999 AAH09999 BI816797 DA449863 XM_005274307 XP_005274364 XM_011545269 XP_011543571 XM_011545270 XP_011543572 XM_011545271 XP_011543573 XR_247212 XR_950067 NM_025128 NP_079404
Function	Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235}.
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:14638871, ECO:0000269|PubMed:15805243}. Note=Recruited to foci of DNA damage in S-phase cells.
Tissue Specificity	Widely expressed.
Top Pathways	Homologous recombination, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-MUS81-cDNA-Clone - DC02833 from Abgent, a WuXi AppTec company Prices $743.85 Sizes 10 µg Species Human Accession BC009999

MUS81 - MBS1270561 from MyBioSource Species Human Accession BC009999

Human MUS81 Gene ORF cDNA clone in cloning vector - HG14854-G from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14854-ACR from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14854-ANR from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14854-NF from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14854-CY from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid - HG14854-UT from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14854-CF from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14854-ACG from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14854-NM from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14854-CM from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14854-NY from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14854-ANG from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, N-His tag - HG14854-NH from Sino Biological Species Human

Human MUS81 Gene ORF cDNA clone expression plasmid, C-His tag - HG14854-CH from Sino Biological Species Human

Mouse MUS81 ORF clone (NM_025128.4) - CDCL135455 from Creative biogene Species Human

Human MUS81 ORF Clone (BC009999) - CDCS415905 from Creative biogene Species Human Accession Q53ES5

Human MUS81 ORF clone (BC009999) - CDCB158718 from Creative biogene Species Human

Human MUS81 Gene cDNA Clone - orb144345 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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