OPRK1

Gene Symbol OPRK1
Entrez Gene 4986
Alt Symbol K-OR-1, KOR, KOR-1, OPRK
Species Human
Gene Type protein-coding
Description opioid receptor, kappa 1
Other Description Opiate receptor, kappa-1|kappa opioid receptor|kappa-type opioid receptor
Swissprots E5RHC9 P41145 Q499G4
Accessions AAA56758 EAW86723 P41145 AF498922 AAM21070 AK023198 AK310233 AK310407 AK313058 BAG35888 AY168006 AAN87342 AY466378 AAR36879 BC099912 AAH99912 BF061371 EF057067 L36130 AAA63646 L37362 AAA63906 U11053 AAA20985 U17298 AAC50158 NM_000912 NP_000903 NM_001282904 NP_001269833
Function G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269
Subcellular Location Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
Tissue Specificity Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
Top Pathways Neuroactive ligand-receptor interaction

KOR-1 (D-8) - sc-374479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
KOR-1 (D-8): sc-374479. Western blot analysis of KOR-1 expression in PC-12 whole cell lysate.

KOR-1 (C-20) - sc-7493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KOR-1 (C-20): sc-7493. Western blot analysis of KOR-1 expression in PC-12 whole cell lysate.

KOR-1 (H-70) - sc-9112 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
KOR-1 (H-70): sc-9112. Western blot analysis of KOR-1 expression in AT-3 whole cell lysate.

KOR-1 (N-19) - sc-7494 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Kappa Opioid Receptor antibody - ab113533 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Kappa Opioid Receptor antibody (ab113533) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188)Lane 3 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lane 4 : Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276)Lane 5 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Kappa Opioid Receptor antibody - ab137264 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Kappa Opioid Receptor antibody (ab137264) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-Kappa Opioid Receptor antibody - ab109979 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Kappa Opioid Receptor antibody (ab109979) at 1 µg/ml + Human cerebral cortex lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-Kappa Opioid Receptor antibody - C-terminal - ab179873 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of HEK293 cells, transiently transfected with Kappa Opioid Receptor labeling Kappa Opioid Receptor with ab179873 at 1/5 dilution (red); DAPI staining (blue).

Anti-Kappa Opioid Receptor antibody - N-terminal - ab194371 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371) at 1/500 dilution + Rat kidney tissue lysate at 50 µgdeveloped using the ECL technique

Anti-OPRK1 / Kappa Opioid Receptor Antibody (aa366-380) IHC-plus™ - LS-B6883 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Kappa Opioid Receptor antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6883 concentration 5 ug/ml.

Anti-OPRK1 / Kappa Opioid Receptor Antibody (C-Terminus) - LS-C37882 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (C-Terminus) - LS-C37883 from LifeSpan Bioscience

Prices $635.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (Internal, Azide-free) - LS-C37885 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (C-Terminus) - LS-C37884 from LifeSpan Bioscience

Prices $435.00
Sizes 5 ml
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (Internal) - LS-C37886 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody - LS-C37887 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (aa181-209, AP) - LS-C264999 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (N-Terminus) - LS-C102843 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OPRK1 / Kappa Opioid Receptor antibody LS-C102843 Western blot of Fetal Brain lysate. Antibody concentration 1 ug/ml.

Anti-OPRK1 / Kappa Opioid Receptor Antibody (aa331-380) - LS-C199174 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using KOR-1 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-OPRK1 / Kappa Opioid Receptor Antibody (aa181-209, APC) - LS-C265000 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (aa312-361) - LS-C200300 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using OPRK1 antibody.

Anti-OPRK1 / Kappa Opioid Receptor Antibody (aa181-209, Biotin) - LS-C265001 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (aa367-379) - LS-C139717 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
OPRK1 antibody (1 ug/ml) staining of Human Cerebral Cortex lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OPRK1 / Kappa Opioid Receptor Antibody (aa181-209, FITC) - LS-C265002 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain) IHC-plus™ - LS-A228 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Kappa Opioid Receptor antibody LS-A228 IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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