| Gene Symbol |
OPRK1
|
| Entrez Gene |
4986
|
| Alt Symbol |
K-OR-1, KOR, KOR-1, OPRK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
opioid receptor, kappa 1
|
| Other Description |
Opiate receptor, kappa-1|kappa opioid receptor|kappa-type opioid receptor
|
| Swissprots |
E5RHC9 P41145 Q499G4
|
| Accessions |
AAA56758 EAW86723 P41145 AF498922 AAM21070 AK023198 AK310233 AK310407 AK313058 BAG35888 AY168006 AAN87342 AY466378 AAR36879 BC099912 AAH99912 BF061371 EF057067 L36130 AAA63646 L37362 AAA63906 U11053 AAA20985 U17298 AAC50158 NM_000912 NP_000903 NM_001282904 NP_001269833
|
| Function |
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
|
| Tissue Specificity |
Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|