OPRK1

Gene Symbol	OPRK1
Entrez Gene	4986
Alt Symbol	K-OR-1, KOR, KOR-1, OPRK
Species	Human
Gene Type	protein-coding
Description	opioid receptor, kappa 1
Other Description	Opiate receptor, kappa-1|kappa opioid receptor|kappa-type opioid receptor
Swissprots	E5RHC9 P41145 Q499G4
Accessions	AAA56758 EAW86723 P41145 AF498922 AAM21070 AK023198 AK310233 AK310407 AK313058 BAG35888 AY168006 AAN87342 AY466378 AAR36879 BC099912 AAH99912 BF061371 EF057067 L36130 AAA63646 L37362 AAA63906 U11053 AAA20985 U17298 AAC50158 NM_000912 NP_000903 NM_001282904 NP_001269833
Function	G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
Tissue Specificity	Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Kappa Opioid Receptor peptide - ab38195 from Abcam Category Peptide Species Human

Human Kappa Opioid Receptor protein fragment - ab114296 from Abcam Category Protein Source Wheat germ Species Human

Kappa Opioid Receptor peptide - ab138734 from Abcam Category Peptide

Kappa Opioid Receptor peptide - ab49411 from Abcam Category Peptide

OPRK1 / Kappa Opioid Receptor Antibody Blocking Peptide - LS-E10710 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

OPRK1 / Kappa Opioid Receptor Antibody Blocking Peptide - LS-E27558 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

OPRK1 / Kappa Opioid Receptor Antibody Blocking Peptide - LS-E28532 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

OPRK1 / Kappa Opioid Receptor Antibody Blocking Peptide - LS-E28539 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KOR Partial Recombinant Protein - H00004986-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

KOR Blocking Peptide - NB100-1660PEP from Novus Biologicals Category Peptide Prices $229.00 Sizes 20 µg Species Human

KOR Recombinant Protein - P3549 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

Kappa Opioid Receptor Blocking Peptide - GTX78189 from GeneTex Category Peptide Prices $179.00 Sizes 20 μg

Kappa Opioid Receptor protein - orb82112 from Biorbyt Category Protein Prices $587.00 Sizes 500 µg Source Sample obtained from Synthetic.

OPRK1 Blocking Peptide - 33R-2172 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

kappa Opioid Receptor Peptide - AC21-2380-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Kappa Opioid Receptor - H00004986-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Kappa Opioid Receptor - H00004986-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Kappa Opioid Receptor - P3549 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

Kappa Opioid Receptor Control Peptide - BA1072 from Acris Antibodies Category Peptide Prices $430.00 Sizes 500 µg

Kappa Opioid Receptor control peptide - SP5454CP from Acris Antibodies Category Peptide Prices $270.00 Sizes 50 µg

Kappa Opioid Receptor / OPRK1 Peptide - MD-19-0034P from RayBiotech Category Peptide

OPRK1 Peptide - 42-712P from ProSci Category Peptide Species Human

Kappa Opioid Receptor - GWB-424F2D from Genway Biotech Category Peptide Prices $473.00 Sizes 500 µg Source Synthetic

Recombinant Human OPRK1 - OPRK1-28446TH from Creative Biomart Category Protein Source Wheat germ Species Human

ChemiScreen™ Membrane Preparation Recombinant Human Kappa Opioid Receptor - HTS095M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

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