OPRK1
| Gene Symbol | OPRK1 |
|---|---|
| Entrez Gene | 4986 |
| Alt Symbol | K-OR-1, KOR, KOR-1, OPRK |
| Species | Human |
| Gene Type | protein-coding |
| Description | opioid receptor, kappa 1 |
| Other Description | Opiate receptor, kappa-1|kappa opioid receptor|kappa-type opioid receptor |
| Swissprots | E5RHC9 P41145 Q499G4 |
| Accessions | AAA56758 EAW86723 P41145 AF498922 AAM21070 AK023198 AK310233 AK310407 AK313058 BAG35888 AY168006 AAN87342 AY466378 AAR36879 BC099912 AAH99912 BF061371 EF057067 L36130 AAA63646 L37362 AAA63906 U11053 AAA20985 U17298 AAC50158 NM_000912 NP_000903 NM_001282904 NP_001269833 |
| Function | G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269 |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}. |
| Tissue Specificity | Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}. |
| Top Pathways | Neuroactive ligand-receptor interaction |
KOR-1 CRISPR/Cas9 KO Plasmid (h) - sc-401354 from Santa Cruz Biotechnology
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KOR-1 HDR Plasmid (h) - sc-401354-HDR from Santa Cruz Biotechnology
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KOR-1 Double Nickase Plasmid (h) - sc-401354-NIC from Santa Cruz Biotechnology
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KOR-1 Double Nickase Plasmid (h2) - sc-401354-NIC-2 from Santa Cruz Biotechnology
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KOR-1 CRISPR Activation Plasmid (h) - sc-401354-ACT from Santa Cruz Biotechnology
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KOR-1 CRISPR Activation Plasmid (h2) - sc-401354-ACT-2 from Santa Cruz Biotechnology
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KOR-1 Lentiviral Activation Particles (h) - sc-401354-LAC from Santa Cruz Biotechnology
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KOR-1 Lentiviral Activation Particles (h2) - sc-401354-LAC-2 from Santa Cruz Biotechnology
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KOR-1 siRNA (h) - sc-35760 from Santa Cruz Biotechnology
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KOR-1 shRNA Plasmid (h) - sc-35760-SH from Santa Cruz Biotechnology
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KOR-1 shRNA (h) Lentiviral Particles - sc-35760-V from Santa Cruz Biotechnology
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KOR RNAi - H00004986-R02 from Novus Biologicals
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MISSION® esiRNA - EHU045831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15745 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15745 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR14135 from Sigma-Aldrich
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OPRK1 siRNA (Human) - CRH3307 from Cohesion Biosciences
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shRNA set against Human OPRK1 (NM_000912.3) - SHH366720 from Creative biogene
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shRNA set against Human OPRK1(NM_000912.3) - SHR071288 from Creative biogene
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OPRK1 shRNA Plasmid (Human) - CHH3307 from Cohesion Biosciences
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OPRK1 miRNA 3'UTR clone - MiUTR1H-07071 from Creative biogene
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