OPRK1

Gene Symbol	OPRK1
Entrez Gene	4986
Alt Symbol	K-OR-1, KOR, KOR-1, OPRK
Species	Human
Gene Type	protein-coding
Description	opioid receptor, kappa 1
Other Description	Opiate receptor, kappa-1|kappa opioid receptor|kappa-type opioid receptor
Swissprots	E5RHC9 P41145 Q499G4
Accessions	AAA56758 EAW86723 P41145 AF498922 AAM21070 AK023198 AK310233 AK310407 AK313058 BAG35888 AY168006 AAN87342 AY466378 AAR36879 BC099912 AAH99912 BF061371 EF057067 L36130 AAA63646 L37362 AAA63906 U11053 AAA20985 U17298 AAC50158 NM_000912 NP_000903 NM_001282904 NP_001269833
Function	G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
Tissue Specificity	Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Kappa-type opioid receptor (OPRK1), ELISA Kit - MBS9338778 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Opioid Receptor Kappa 1 (OPRk1), ELISA Kit - MBS2024863 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.28ng/mL. Range 0.781-50ng/mL

ELISA Kit for Opioid Receptor Kappa 1 (OPRk1) - SED043Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.28ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Mouse OPRK1 / Kappa Opioid Receptor ELISA Kit (Sandwich ELISA) - LS-F25404 from LifeSpan Bioscience Category ELISA Kit Prices $800.00 Sizes 1 plate Sensitivity 0.28 ng/ml Range 0.781-50 ng/ml

Human OPRK1 ELISA Kit - E021338 from Biobool Category ELISA Kit

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392136 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392144 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392129 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392132 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392130 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392131 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392135 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392140 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392133 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392137 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392139 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392138 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392134 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392141 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392142 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392143 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392145 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392146 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kappa-Type Opioid Receptor (OPRK1), ELISA Kit - MBS9392147 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat OPRK1 / Kappa Opioid Receptor ELISA Kit (Sandwich ELISA) - LS-F32210 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.469 Range 0.781-50 ng/ml

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