| Gene Symbol |
IL36G
|
| Entrez Gene |
56300
|
| Alt Symbol |
IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 36, gamma
|
| Other Description |
IL-1 epsilon|IL-1 related protein 2|IL-1(EPSILON)|IL-1-epsilon|IL-1-related protein 2|interleukin 1 family, member 9|interleukin 1-related protein 2|interleukin-1 epsilon|interleukin-1 family member 9|interleukin-1 homolog 1|interleukin-36 gamma
|
| Swissprots |
Q6UVX7 Q9NZH8 Q56B91 Q7RTZ9
|
| Accessions |
AAX59035 AAY14987 CAD29874 EAW73613 Q9NZH8 AF200492 AAF69248 AF206696 AAG35670 AY359111 AAQ89469 BC096721 AAH96721 BC098130 AAH98130 BC098155 AAH98155 BC098337 AAH98337 XM_011511498 XP_011509800 NM_001278568 NP_001265497 NM_019618 NP_062564
|
| Function |
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activat
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:20870894}.
|
| Tissue Specificity |
Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up- regulated in lesional psoriasis skin. Expressed in monocyte- derived dendritic cells and M1 macrophages. {ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:23095752}.
|
![Western Blot: IL1F9 Overexpression Lysate (Adult Normal) [NBP2-06704] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL1F9.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8222_IL1F9%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06704-img0001.jpg)