IL36G

Gene Symbol	IL36G
Entrez Gene	56300
Alt Symbol	IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2
Species	Human
Gene Type	protein-coding
Description	interleukin 36, gamma
Other Description	IL-1 epsilon|IL-1 related protein 2|IL-1(EPSILON)|IL-1-epsilon|IL-1-related protein 2|interleukin 1 family, member 9|interleukin 1-related protein 2|interleukin-1 epsilon|interleukin-1 family member 9|interleukin-1 homolog 1|interleukin-36 gamma
Swissprots	Q6UVX7 Q9NZH8 Q56B91 Q7RTZ9
Accessions	AAX59035 AAY14987 CAD29874 EAW73613 Q9NZH8 AF200492 AAF69248 AF206696 AAG35670 AY359111 AAQ89469 BC096721 AAH96721 BC098130 AAH98130 BC098155 AAH98155 BC098337 AAH98337 XM_011511498 XP_011509800 NM_001278568 NP_001265497 NM_019618 NP_062564
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activat
Subcellular Location	Secreted {ECO:0000269|PubMed:20870894}.
Tissue Specificity	Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up- regulated in lesional psoriasis skin. Expressed in monocyte- derived dendritic cells and M1 macrophages. {ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:23095752}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL36 gamma protein fragment - ab138902 from Abcam Category Protein Prices $110.00, $192.00 Sizes 2 µg, 10 µg Source E. coli Species Human

Human IL36 gamma full length protein - ab167874 from Abcam Category Protein Source E. coli Species Human

Human IL36 gamma full length protein - ab193859 from Abcam Category Protein Source Mammalian Species Human

Recombinant Human IL-36 gamma/IL-1F9 Protein - NBP2-34891 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

Recombinant Human IL-36 gamma/IL-1F9 Protein - NBP2-34892 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

IL1F9 Partial Recombinant Protein - H00056300-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human IL1F9 Protein - NBP2-23151 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

IL1F9 recombinant protein - GTX53811 from GeneTex Category Protein Prices $199.00 Sizes 10 μg Source E. Coli

Recombinant Human IL-36 gamma/IL-1F9 (aa 18-169) - 6835-IL-010 from R&D Systems Category Protein Source E. coli-derived, Ser18-Asp169

Recombinant Human IL-36 gamma/IL-1F9 (aa 18-169), CF - 6835-IL-010/CF from R&D Systems Category Protein Source E. coli-derived, Ser18-Asp169

Recombinant Human IL-36 gamma/IL-1F9 - 2320-IL-025 from R&D Systems Category Protein Source E. coli-derived, Met1-Asp169

Recombinant Human IL-36 gamma/IL-1F9, CF - 2320-IL-025/CF from R&D Systems Category Protein Source E. coli-derived, Met1-Asp169

Human IL36G protein (His Tag) - orb191321 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human IL1F9 protein (His Tag) - orb139153 from Biorbyt Category Protein Prices $357.00, $510.00 Sizes 10 μg, 20 μg Source E. coli Species Human

Human IL36G protein - orb168605 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human IL1F9 protein - orb139154 from Biorbyt Category Protein Prices $298.00, $400.00 Sizes 10 μg, 20 μg Source E. coli Species Human

Human IL1F9 protein (Native) - orb139152 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Mouse IL36G protein - orb168606 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

IL36G protein (His tag) - 80R-2942 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Human IL1F9 Protein - abx067397 from Abbexa Category Protein Source E.coli Species Human

IL1F9 / IL1H1 - AR31088PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source E. coli Species Human

IL1F9 / IL1H1 - AR31088PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 2 µg Source E. coli Species Human

IL1F9 / IL1H1 (1-169, His-tag) - AR51060PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

IL1F9 / IL1H1 (1-169, His-tag) - AR51060PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

IL1F9 / IL1H1 - H00056300-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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